asp-5 Peptidase A1 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: asp-5
Official Full Name: Peptidase A1 domain-containing protein
Primary source: WormBase:WBGene00000218
Locus tag: CELE_F21F8.3
See related: AllianceGenome:WB:WBGene00000218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be active in lysosome. Is expressed in intestine. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See asp-5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (8272385..8274044)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS5-275 (e-PCR)
- UniSTS:242444

F21F8.3 (e-PCR)
- UniSTS:312279

F21F8.4 (e-PCR)
- UniSTS:312280

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peptidase A1 domain-containing protein

NP_505135.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8272385..8274044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072734.8 → NP_505135.1 Peptidase A1 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505135.1

Status: REVIEWED

UniProtKB/TrEMBL

O01532

Conserved Domains (1) summary

pfam00026
Location:72 → 387

Asp; Eukaryotic aspartyl protease