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    acc-1 Acetylcholine-gated chloride channel subunit acc-1;Ligand-gated ion channel 50 [ Caenorhabditis elegans ]

    Gene ID: 177799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acc-1
    Official Full Name
    Acetylcholine-gated chloride channel subunit acc-1;Ligand-gated ion channel 50
    Primary source
    WormBase:WBGene00010275
    Locus tag
    CELE_F58G6.4
    See related
    AllianceGenome:WB:WBGene00010275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in ganglia and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (9658053..9663983)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Copper transport protein Neighboring gene Copper transport protein Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-34 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigating the function and possible biological role of an acetylcholine-gated chloride channel subunit (ACC-1) from the parasitic nematode Haemonchus contortus. Callanan MK, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30401619, Free PMC Article
    2. Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes. Beech RN, et al. Parasitol Int, 2013 Dec. PMID 23602737
    3. Locomotion modulates olfactory learning through proprioception in C. elegans. Zhan X, et al. Nat Commun, 2023 Jul 27. PMID 37500635, Free PMC Article
    4. An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction. Sando SR, et al. Elife, 2021 Jul 2. PMID 34212858, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acetylcholine-gated chloride channel subunit acc-1;Ligand-gated ion channel 50
    NP_001293865.1
    • Confirmed by transcript evidence
    NP_501715.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9658053..9663983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069314.8 → NP_501715.1  Acetylcholine-gated chloride channel subunit acc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21005
      Conserved Domains (1) summary
      cl27321
      Location:35 → 449
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

    2. NM_001306936.3 → NP_001293865.1  Ligand-gated ion channel 50 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACH3
      Conserved Domains (3) summary
      TIGR00860
      Location:39 → 453
      LIC; Cation transporter family protein
      pfam02931
      Location:38 → 243
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:251 → 450
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21005.2

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