dpy-27 Chromosome condensation protein dpy-27 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpy-27
Official Full Name: Chromosome condensation protein dpy-27
Primary source: WormBase:WBGene00001086
Locus tag: CELE_R13G10.1
See related: AllianceGenome:WB:WBGene00001086
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dpy-27 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (3813018..3819679, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings identify a Structural Maintenance of Chromosomes (SMC)-like protein, SMCL-1 (C44C10.4), that binds to condensin subunits dpy-26, dpy-27 and dpy-28 and modulates condensin functions.
Title: An SMC-like protein binds and regulates Caenorhabditis elegans condensins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13G10.1 (e-PCR)
- UniSTS:321647

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in dosage compensation by hypoactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dosage compensation complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Chromosome condensation protein dpy-27

NP_497771.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3813018..3819679 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065370.7 → NP_497771.1 Chromosome condensation protein dpy-27 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497771.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48996

Conserved Domains (3) summary

COG1196
Location:91 → 1322

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06470
Location:620 → 736

SMC_hinge; SMC proteins Flexible Hinge Domain

cl21455
Location:1235 → 1331

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases