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    dnj-20 DnaJ homolog dnj-20 [ Caenorhabditis elegans ]

    Gene ID: 174514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnj-20
    Official Full Name
    DnaJ homolog dnj-20
    Primary source
    WormBase:WBGene00001038
    Locus tag
    CELE_T15H9.7
    See related
    AllianceGenome:WB:WBGene00001038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable misfolded protein binding activity and unfolded protein binding activity. Predicted to be involved in protein maturation. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnj-20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (9617469..9624176, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Helix-loop-helix protein 6 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Glucosidase 2 subunit beta Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Anaphase-promoting complex subunit 4-like WD40 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DnaJ homolog dnj-20
    NP_001370249.1
    • Confirmed by transcript evidence
    NP_496072.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9617469..9624176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383920.2 → NP_001370249.1  DnaJ homolog dnj-20 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GWA8, Q10005, Q8MPX3
      Conserved Domains (1) summary
      COG0484
      Location:23 → 350
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_063671.7 → NP_496072.2  DnaJ homolog dnj-20 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496072.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MPX3
      Conserved Domains (1) summary
      cl21722
      Location:1 → 54
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MPX3.2

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