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    lipl-4 Lipase lipl-4 [ Caenorhabditis elegans ]

    Gene ID: 179046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lipl-4
    Official Full Name
    Lipase lipl-4
    Primary source
    WormBase:WBGene00019376
    Locus tag
    CELE_K04A8.5
    See related
    AllianceGenome:WB:WBGene00019376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables triacylglycerol lipase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macroautophagy; and triglyceride catabolic process. Located in lysosome. Is expressed in intestine and seam cell. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lipl-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (6550171..6552186)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene Potassium channel domain-containing protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Saposin B-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases. Shemesh N, et al. Front Mol Neurosci, 2017. PMID 28503130, Free PMC Article
    2. Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans. Liu YJ, et al. Sci Rep, 2022 Mar 1. PMID 35233004, Free PMC Article
    3. Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. Ramachandran PV, et al. Dev Cell, 2019 Mar 11. PMID 30713071, Free PMC Article
    4. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Folick A, et al. Science, 2015 Jan 2. PMID 25554789, Free PMC Article
    5. Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans. Wu Z, et al. Molecules, 2022 Sep 20. PMID 36234692, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
      Title: Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.
    2. Autophagy and lipase LIPL-4 modulate aging in germline-deficient C. elegans by maintaining lipid homeostasis to prolong life span.
      Title: Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
    3. germline stem cell arrest promotes lipolysis via induction of lipase; fat mobilization is promoted & life span prolonged; constitutive expression of this lipase in fat storage tissue generates lean, long-lived animals
      Title: Fat metabolism links germline stem cells and longevity in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lipase lipl-4
    NP_001300136.1
    • Confirmed by transcript evidence
    NP_504662.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6550171..6552186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072261.5 → NP_504662.1  Lipase lipl-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AUZ3, Q94252
      Conserved Domains (1) summary
      PLN02872
      Location:38 → 399
      PLN02872; triacylglycerol lipase

    2. NM_001313207.3 → NP_001300136.1  Lipase lipl-4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUZ3
      Conserved Domains (1) summary
      PLN02872
      Location:14 → 242
      PLN02872; triacylglycerol lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94252.1

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