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    hum-8 Myosin motor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hum-8
    Official Full Name
    Myosin motor domain-containing protein
    Primary source
    WormBase:WBGene00002041
    Locus tag
    CELE_Y66H1A.6
    See related
    AllianceGenome:WB:WBGene00002041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hum-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (429209..440554, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative H/ACA ribonucleoprotein complex subunit 1-like protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene ncRNA Neighboring gene 39S ribosomal protein L55, mitochondrial Neighboring gene Dolichol-phosphate mannosyltransferase subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The two C. elegans class VI myosins, SPE-15/HUM-3 and HUM-8, share similar motor properties, but have distinct developmental and tissue expression patterns. Behbehani R, et al. Front Physiol, 2024. PMID 38660538, Free PMC Article
    2. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article
    3. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article
    4. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
    5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Myosin motor domain-containing protein
    NP_001023548.2
    • Confirmed by transcript evidence
    NP_001294574.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      429209..440554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307645.3 → NP_001294574.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBY2
      Conserved Domains (4) summary
      TIGR02794
      Location:983 → 1076
      tolA_full; TolA protein
      cd01382
      Location:143 → 825
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:1180 → 1274
      Myosin-VI_CBD; Myosin VI cargo binding domain
      pfam17380
      Location:882 → 1071
      DUF5401; Family of unknown function (DUF5401)

    2. NM_001028377.5 → NP_001023548.2  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023548.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0I7
      Conserved Domains (4) summary
      TIGR02794
      Location:983 → 1076
      tolA_full; TolA protein
      cd01382
      Location:143 → 825
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:1180 → 1260
      Myosin-VI_CBD; Myosin VI cargo binding domain
      pfam17380
      Location:882 → 1071
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein
    Heading Accession and Version

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