ddr-2 Discoidin domain-containing receptor tyrosine kinase B [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ddr-2
Official Full Name: Discoidin domain-containing receptor tyrosine kinase B
Primary source: WormBase:WBGene00017381
Locus tag: CELE_F11D5.3
See related: AllianceGenome:WB:WBGene00017381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein tyrosine kinase activity. Involved in axon guidance; peptidyl-tyrosine phosphorylation; and positive regulation of axon regeneration. Located in axon and plasma membrane. Is expressed in several structures, including anal depressor muscle; arcade cell; hypodermis; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including alcoholic liver cirrhosis; bone disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and skin melanoma. Orthologous to several human genes including DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddr-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 14

Sequence:: Chromosome: X; NC_003284.9 (3315314..3324242)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of svh-2, but not of ddr-2, can suppress the axon regeneration defect observed in svh-11 mutants, suggesting that SVH-11 functions between DDR-2 and SVH-2 in this glycosylation pathway. Furthermore, we found that DDR-2 is N-glycosylated at the Asn-141 residue located in its discoidin domain, and mutation of this residue caused an axon regeneration defect.
Title: N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans.
the scaffold protein SHC-1 interacts with both DDR-2 and SVH-2. Furthermore, we demonstrate that overexpression of svh-2 and shc-1 suppresses the delay in axon regeneration observed in ddr-2 mutants, suggesting that DDR-2 functions upstream of SVH-2 and SHC-1
Title: The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration.
Discoidin domain receptors guide axons along longitudinal tracts in C. elegans
Title: Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F11D5.3 (e-PCR)
- UniSTS:309691

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interneuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interneuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Discoidin domain-containing receptor tyrosine kinase B

NP_508572.1

Confirmed by transcript evidence

NP_508573.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3315314..3324242

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076171.7 → NP_508572.1 Discoidin domain-containing receptor tyrosine kinase B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508572.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95ZV6, Q95ZV7

Conserved Domains (4) summary

smart00219
Location:527 → 785

TyrKc; Tyrosine kinase, catalytic domain

smart00231
Location:24 → 181

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:29 → 180

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:521 → 787

PKc_like; Protein Kinases, catalytic domain
NM_076172.9 → NP_508573.1 Discoidin domain-containing receptor tyrosine kinase B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508573.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95ZV7

Conserved Domains (4) summary

smart00219
Location:497 → 755

TyrKc; Tyrosine kinase, catalytic domain

smart00231
Location:7 → 151

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:8 → 150

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl21453
Location:491 → 757

PKc_like; Protein Kinases, catalytic domain