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    rpn-8 MPN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172009, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpn-8
    Official Full Name
    MPN domain-containing protein
    Primary source
    WormBase:WBGene00004464
    Locus tag
    CELE_R12E2.3
    See related
    AllianceGenome:WB:WBGene00004464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallopeptidase activity. Involved in programmed cell death involved in cell development. Predicted to be part of proteasome complex. Is expressed in several structures, including enteric muscle; excretory cell; intestine; nervous system; and reproductive system. Orthologous to human PSMD7 (proteasome 26S subunit, non-ATPase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpn-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (4175319..4177271)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Orotate phosphoribosyltransferase Neighboring gene Small ribosomal subunit protein bS6m Neighboring gene ncRNA Neighboring gene MIR domain-containing protein Neighboring gene SUN domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasomal subunit depletions differentially affect germline integrity in C. elegans. Fernando LM, et al. Front Cell Dev Biol, 2022. PMID 36060813, Free PMC Article
    2. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
    3. HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. Kinet MJ, et al. Elife, 2016 Mar 8. PMID 26952214, Free PMC Article
    4. Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1. Huang S, et al. Development, 2007 Jul. PMID 17567664
    5. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Lehrbach NJ, et al. Elife, 2019 Apr 11. PMID 30973820, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MPN domain-containing protein
    NP_491319.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4175319..4177271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058918.8 → NP_491319.1  MPN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61792
      Conserved Domains (1) summary
      cd08062
      Location:39 → 320
      MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
    Nucleotide Protein
    Heading Accession and Version

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