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    let-49 Mediator of RNA polymerase II transcription subunit 7 [ Caenorhabditis elegans ]

    Gene ID: 173353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    let-49
    Official Full Name
    Mediator of RNA polymerase II transcription subunit 7
    Primary source
    WormBase:WBGene00002324
    Locus tag
    CELE_Y54E5B.3
    See related
    AllianceGenome:WB:WBGene00002324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription coregulator activity. Involved in embryo development. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See let-49 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (14820405..14821651)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sema domain-containing protein;Semaphorin-1A Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Ubiquitin-conjugating enzyme E2 W Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans. Kwon JY, et al. FEBS Lett, 2001 Nov 23. PMID 11728440
    2. Genetic fine structure analysis of the myosin heavy chain gene unc-54 of Caenorhabditis elegans. Waterston RH, et al. J Mol Biol, 1982 Jun 15. PMID 7120406
    3. Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans. Holway AH, et al. Genetics, 2005 Mar. PMID 15654100, Free PMC Article
    4. A selection for myosin heavy chain mutants in the nematode Caenorhabditis elegans. Anderson P, et al. Proc Natl Acad Sci U S A, 1984 Jul. PMID 6589606, Free PMC Article
    5. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Kwon JY, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611325, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mediator of RNA polymerase II transcription subunit 7
    NP_493585.1
    • Confirmed by transcript evidence
    NP_493586.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14820405..14821651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061185.9 → NP_493586.1  Mediator of RNA polymerase II transcription subunit 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q17, Q9XWF7
      Conserved Domains (1) summary
      pfam05983
      Location:10 → 165
      Med7; MED7 protein

    2. NM_061184.6 → NP_493585.1  Mediator of RNA polymerase II transcription subunit 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Q17
      Conserved Domains (1) summary
      pfam05983
      Location:10 → 167
      Med7; MED7 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95Q17.1

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