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    lon-1 Protein lon-1;SCP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lon-1
    Official Full Name
    Protein lon-1;SCP domain-containing protein
    Primary source
    WormBase:WBGene00003055
    Locus tag
    CELE_F48E8.1
    See related
    AllianceGenome:WB:WBGene00003055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including negative regulation of BMP signaling pathway; negative regulation of DNA endoreduplication; and positive regulation of growth rate. Located in adherens junction and plasma membrane. Is expressed in head; hypodermis; intestine; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lon-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5474476..5478005)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MRH domain-containing protein Neighboring gene FAD-dependent oxidoreductase 2 FAD binding domain-containing protein Neighboring gene E2F-associated phosphoprotein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Uncharacterized protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Myb-binding protein 1A-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein lon-1;SCP domain-containing protein
    NP_001367873.1
    • Confirmed by transcript evidence
    NP_498166.1
    • Confirmed by transcript evidence
    NP_498167.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5474476..5478005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065766.7 → NP_498167.1  SCP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L058
      Conserved Domains (1) summary
      smart00198
      Location:81 → 211
      SCP; SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains

    2. NM_065765.9 → NP_498166.1  Protein lon-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09566
      Conserved Domains (1) summary
      smart00198
      Location:81 → 211
      SCP; SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains

    3. NM_001379712.2 → NP_001367873.1  SCP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ33
      Conserved Domains (1) summary
      smart00198
      Location:81 → 211
      SCP; SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09566.1

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