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    grh-1 CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grh-1
    Official Full Name
    CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein
    Primary source
    WormBase:WBGene00001707
    Locus tag
    CELE_Y48G8AR.1
    See related
    AllianceGenome:WB:WBGene00001707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Involved in defense response to bacterium; determination of adult lifespan; and ecdysis, collagen and cuticulin-based cuticle. Located in chromatin and nucleus. Is expressed in head neurons; hypodermis; pharyngeal cell; and vulval precursor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL1 (grainyhead like transcription factor 1); GRHL2 (grainyhead like transcription factor 2); and GRHL3 (grainyhead like transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See grh-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (1258201..1268155, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene HECT domain-containing protein Neighboring gene ncRNA Neighboring gene nucleoside-diphosphate kinase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPIRE, a modular pipeline for eQTL analysis of RNA-Seq data, reveals a regulatory hotspot controlling miRNA expression in C. elegans. Kel I, et al. Mol Biosyst, 2016 Oct 18. PMID 27722582
    2. Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead. Venkatesan K, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888489, Free PMC Article
    3. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Grigolon G, et al. Nat Commun, 2022 Jan 10. PMID 35013237, Free PMC Article
    4. Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A. Rozanov L, et al. Redox Biol, 2020 May. PMID 32203922, Free PMC Article
    5. C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1. Meeuse MWM, et al. EMBO J, 2023 Feb 15. PMID 36688410, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.
      Title: C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.
    2. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
      Title: Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
    3. characterized GRH-1 a member of an ancient duplicated transcription factor family, LSF/Grainyhead; phenotype similar to Drosophila grainyhead mutants, suggesting conservation of the developmental role of these family members during evolution (GRH-1).
      Title: Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CP2 domain-containing protein;Grainyhead-like protein 1 homolog;Grh/CP2 DB domain-containing protein
    NP_001293411.1
    • Partially confirmed by transcript evidence
    NP_001293412.1
    • Partially confirmed by transcript evidence
    NP_490837.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1258201..1268155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058436.6 → NP_490837.2  Grainyhead-like protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490837.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDF0
      Conserved Domains (1) summary
      pfam04516
      Location:198 → 385
      CP2; CP2 transcription factor

    2. NM_001306482.4 → NP_001293411.1  Grh/CP2 DB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RT88
      Conserved Domains (1) summary
      pfam04516
      Location:198 → 386
      CP2; CP2 transcription factor

    3. NM_001306483.3 → NP_001293412.1  CP2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SB79
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDF0.1

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