gad-1 Gastrulation defective protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gad-1
Official Full Name: Gastrulation defective protein 1
Primary source: WormBase:WBGene00001513
Locus tag: CELE_T05H4.14
See related: AllianceGenome:WB:WBGene00001513
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in cell migration involved in gastrulation; establishment of mitotic spindle orientation; and regulation of mitotic cell cycle. Predicted to be active in nucleus and site of double-strand break. Is expressed in germ line. Orthologous to human WDR70 (WD repeat domain 70). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gad-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (6431333..6433496, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05H4.14 (e-PCR)
- UniSTS:310691

T05H4.6 (e-PCR)
- UniSTS:310694

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Gastrulation defective protein 1

NP_504635.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6431333..6433496 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072234.6 → NP_504635.1 Gastrulation defective protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504635.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16519

Conserved Domains (3) summary

COG2319
Location:139 → 470

WD40; WD40 repeat [General function prediction only]

sd00039
Location:126 → 168

7WD40; WD40 repeat [structural motif]

cl02567
Location:123 → 445

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...