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    anmt-2 Nicotinamide N-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 175868, updated on 9-Dec-2024

    Summary

    Official Symbol
    anmt-2
    Official Full Name
    Nicotinamide N-methyltransferase
    Primary source
    WormBase:WBGene00018340
    Locus tag
    CELE_F42A10.3
    See related
    AllianceGenome:WB:WBGene00018340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable N-methyltransferase activity. Predicted to be involved in methylation. Predicted to be active in cytosol. Is expressed in several structures, including ABalpaaapa; ABalpaapap; ABaraapapa; MSaaaapp; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; abdominal aortic aneurysm; hypertension; and multiple sclerosis. Orthologous to several human genes including INMT (indolethylamine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See anmt-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (6154844..6157758, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene ncRNA Neighboring gene Nbl1_Borealin_N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene tRNA-Ser

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Nicotinamide N-methyltransferase
    NP_498334.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6154844..6157758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065933.10NP_498334.1  Nicotinamide N-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20308
      Conserved Domains (1) summary
      pfam01234
      Location:13273
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family