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    trx-3 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trx-3
    Official Full Name
    Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00019717
    Locus tag
    CELE_M01H9.1
    See related
    AllianceGenome:WB:WBGene00019717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in photoreceptor cell maintenance and sensory perception. Located in apical plasma membrane; cytoplasm; and nucleus. Is expressed in intestine. Orthologous to human NXNL2 (nucleoredoxin like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trx-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (4487028..4489000)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PhoLip_ATPase_C domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gamma-aminobutyric acid type B receptor subunit 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein sleepless

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of thioredoxin 3 (TRX-3), a Caenorhabditis elegans intestine-specific thioredoxin. Jiménez-Hidalgo M, et al. Free Radic Biol Med, 2014 Mar. PMID 24316195, Free PMC Article
    2. The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner. Ruszkiewicz JA, et al. Neurotoxicology, 2018 Sep. PMID 30138651
    3. TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans. McCallum KC, et al. Genetics, 2016 May. PMID 26920757, Free PMC Article
    4. Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans. Romero-Afrima L, et al. Redox Biol, 2020 Jan. PMID 31677552, Free PMC Article
    5. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in photoreceptor cell maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Thioredoxin domain-containing protein
    NP_500578.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4487028..4489000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068177.3 → NP_500578.2  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500578.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94282
      Conserved Domains (1) summary
      cd02964
      Location:11 → 132
      TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...
    Nucleotide Protein
    Heading Accession and Version

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