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    mafr-1 Repressor of RNA polymerase III transcription MAF1 [ Caenorhabditis elegans ]

    Gene ID: 172953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mafr-1
    Official Full Name
    Repressor of RNA polymerase III transcription MAF1
    Primary source
    WormBase:WBGene00016622
    Locus tag
    CELE_C43H8.2
    See related
    AllianceGenome:WB:WBGene00016622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase III core binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase III. Located in cytoplasm and nucleus. Is expressed in hypodermis and intestine. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mafr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (10623173..10624361)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DRBM domain-containing protein Neighboring gene tRNA-Gly Neighboring gene Laminin subunit alpha lam-3 Neighboring gene Protein archease-like Neighboring gene ATP-dependent RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation. Hammerquist AM, et al. Mol Biol Cell, 2021 May 15. PMID 33788576, Free PMC Article
    2. The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. Pradhan A, et al. J Mol Biol, 2017 Jan 20. PMID 27986570, Free PMC Article
    3. Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion. Cai Y, et al. Oncotarget, 2016 Mar 8. PMID 26934328, Free PMC Article
    4. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Khanna A, et al. Cell Rep, 2014 Dec 24. PMID 25497095, Free PMC Article
    5. Maf1 phenotypes and cell physiology. Willis IM. Biochim Biophys Acta Gene Regul Mech, 2018 Apr. PMID 29248739, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation.
      Title: Maf1 regulates intracellular lipid homeostasis in response to DNA damage response activation.
    2. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans.
      Title: Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans.
    3. MAFR-1 impacts lipid transport by modulating intestinal expression of the vitellogenin family of proteins, resulting in cell-nonautonomous defects in the developing reproductive system.
      Title: Physiological roles for mafr-1 in reproduction and lipid homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase III core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Repressor of RNA polymerase III transcription MAF1
    NP_492777.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10623173..10624361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060376.5 → NP_492777.1  Repressor of RNA polymerase III transcription MAF1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZN2
      Conserved Domains (1) summary
      pfam09174
      Location:25 → 217
      Maf1; Maf1 regulator
    Nucleotide Protein
    Heading Accession and Version

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