jmjd-3.2 JmjC domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: jmjd-3.2
Official Full Name: JmjC domain-containing protein
Primary source: WormBase:WBGene00009089
Locus tag: CELE_F23D12.5
See related: AllianceGenome:WB:WBGene00009089
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See jmjd-3.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (14448210..14453567)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
Title: H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23D12.5 (e-PCR)
- UniSTS:309911

STS6-205 (e-PCR)
- UniSTS:242590

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27me2/H3K27me3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: JmjC domain-containing protein

NP_510405.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14448210..14453567

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078004.6 → NP_510405.1 JmjC domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510405.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19760

Conserved Domains (3) summary

smart00558
Location:577 → 641

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

COG5644
Location:40 → 191

COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]

pfam02373
Location:611 → 719

JmjC; JmjC domain, hydroxylase