tig-2 TGF-beta family profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: tig-2
Official Full Name: TGF-beta family profile domain-containing protein
Primary source: WormBase:WBGene00006570
Locus tag: CELE_F39G3.8
See related: AllianceGenome:WB:WBGene00006570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in cholinergic neurons; pharyngeal muscle cell; and touch receptor neurons. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including BMP5 (bone morphogenetic protein 5); BMP7 (bone morphogenetic protein 7); and BMP8A (bone morphogenetic protein 8a). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See tig-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (4726721..4730161, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that transformIng Growth factor beta (TGFbeta)/BMP-exerted control operated primarily in the anterior gut and depended on multi-tissue contributions.
Title: TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F39G3.8 (e-PCR)
- UniSTS:314269

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: TGF-beta family profile domain-containing protein

NP_504271.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4726721..4730161 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071870.6 → NP_504271.1 TGF-beta family profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504271.1

Status: REVIEWED

UniProtKB/TrEMBL

O16273

Conserved Domains (1) summary

cd13761
Location:264 → 366

TGF_beta_BMP5_like; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins