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    ifta-1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifta-1
    Official Full Name
    Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
    Primary source
    WormBase:WBGene00016935
    Locus tag
    CELE_C54G7.4
    See related
    AllianceGenome:WB:WBGene00016935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in chemotaxis; intraciliary transport; and non-motile cilium assembly. Located in axoneme and ciliary basal body. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifta-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (5545587..5552752, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene SAP30_Sin3_bdg domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Li JB, et al. Cell, 2004 May 14. PMID 15137946
    2. Functional genomics of intraflagellar transport-associated proteins in C. elegans. Inglis PN, et al. Methods Cell Biol, 2009. PMID 20409822
    3. Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Piasecki BP, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615967, Free PMC Article
    4. The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport. Blacque OE, et al. Mol Biol Cell, 2006 Dec. PMID 17021254, Free PMC Article
    5. An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration. Sun Y, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37722038, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate that IFTA-1 is a novel IFT protein that is required for retrograde transport along ciliary axonemes.
      Title: The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
    NP_508940.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5545587..5552752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076539.7 → NP_508940.4  Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508940.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18859
      Conserved Domains (3) summary
      COG2319
      Location:31 → 210
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:38 → 87
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:334 → 392
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    Nucleotide Protein
    Heading Accession and Version

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