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    chup-1 Cholesterol uptake protein 1 [ Caenorhabditis elegans ]

    Gene ID: 181125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chup-1
    Official Full Name
    Cholesterol uptake protein 1
    Primary source
    WormBase:WBGene00006477
    Locus tag
    CELE_ZK721.1
    See related
    AllianceGenome:WB:WBGene00006477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cholesterol binding activity. Involved in cholesterol import. Located in several cellular components, including Golgi apparatus; endosome; and lysosome. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; pharynx; and reproductive system. Orthologous to several human genes including SIDT1 (SID1 transmembrane family member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chup-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (8792160..8796110)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Troponin I 2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ATP-dependent RNA helicase RhlE;JmjC domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiwindow SRS Imaging Using a Rapid Widely Tunable Fiber Laser. Ni H, et al. Anal Chem, 2021 Nov 30. PMID 34787995, Free PMC Article
    2. Assessing cholesterol storage in live cells and C. elegans by stimulated Raman scattering imaging of phenyl-Diyne cholesterol. Lee HJ, et al. Sci Rep, 2015 Jan 22. PMID 25608867, Free PMC Article
    3. Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8. Otarigho B, et al. iScience, 2020 May 22. PMID 32361270, Free PMC Article
    4. SID-1 Domains Important for dsRNA Import in Caenorhabditis elegans. Whangbo JS, et al. G3 (Bethesda), 2017 Dec 4. PMID 29025917, Free PMC Article
    5. CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. Valdes VJ, et al. PLoS One, 2012. PMID 22479487, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cholesterol uptake protein 1
    NP_509489.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8792160..8796110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077088.8 → NP_509489.1  Cholesterol uptake protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509489.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7YH04, A7YH06, Q9GYF0
      Conserved Domains (1) summary
      pfam13965
      Location:151 → 756
      SID-1_RNA_chan; dsRNA-gated channel SID-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GYF0.1

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