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    lin-8 Protein lin-8 [ Caenorhabditis elegans ]

    Gene ID: 173652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-8
    Official Full Name
    Protein lin-8
    Primary source
    WormBase:WBGene00002997
    Locus tag
    CELE_B0454.1
    See related
    AllianceGenome:WB:WBGene00002997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of vulval development. Located in nucleus. Is expressed in germ line; head neurons; and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (3056822..3060207)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class I Neighboring gene LIn-8 Domain containing Neighboring gene Protein aurora borealis Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Beitel GJ, et al. Gene, 2000 Aug 22. PMID 10974557
    2. lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Davison EM, et al. Genetics, 2005 Nov. PMID 16020796, Free PMC Article
    3. Restriction of Cellular Plasticity of Differentiated Cells Mediated by Chromatin Modifiers, Transcription Factors and Protein Kinases. Rahe DP, et al. G3 (Bethesda), 2019 Jul 9. PMID 31088904, Free PMC Article
    4. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Ferguson EL, et al. Genetics, 1989 Sep. PMID 2806880, Free PMC Article
    5. The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Davison EM, et al. Genetics, 2011 Mar. PMID 21196525, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Controls vulval induction through the transcriptional regulation of gene expression.
      Title: lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lin-8
    NP_494436.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3056822..3060207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062035.7 → NP_494436.1  Protein lin-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDW7
      Conserved Domains (1) summary
      pfam03353
      Location:39 → 384
      Lin-8; Ras-mediated vulval-induction antagonizt
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDW7.1

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