ZK1321.4 PDZ domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ZK1321.4
Official Full Name: PDZ domain-containing protein
Primary source: WormBase:WBGene00014262
Locus tag: CELE_ZK1321.4
See related: AllianceGenome:WB:WBGene00014262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ZK1321.4 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (9770749..9773942, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1321.4 (e-PCR)
- UniSTS:312922

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables muscle alpha-actinin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle structure development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PDZ domain-containing protein

NP_001254227.1

Confirmed by transcript evidence

NP_001254228.1

Confirmed by transcript evidence

NP_001379145.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9770749..9773942 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267298.4 → NP_001254227.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254227.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFP2

Conserved Domains (3) summary

smart00735
Location:340 → 365

ZM; ZASP-like motif

cd00992
Location:5 → 84

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:343 → 423

DUF4749; Domain of unknown function (DUF4749)
NM_001267299.4 → NP_001254228.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254228.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDL9

Conserved Domains (3) summary

smart00735
Location:346 → 371

ZM; ZASP-like motif

cd00992
Location:11 → 90

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:349 → 429

DUF4749; Domain of unknown function (DUF4749)
NM_001393167.1 → NP_001379145.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A679L8N1

Conserved Domains (1) summary

cd00992
Location:5 → 81

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...