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    dog-1 Helicase ATP-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dog-1
    Official Full Name
    Helicase ATP-binding domain-containing protein
    Primary source
    WormBase:WBGene00001049
    Locus tag
    CELE_F33H2.1
    See related
    AllianceGenome:WB:WBGene00001049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA helicase activity. Involved in DNA metabolic process and regulation of DNA-templated DNA replication. Predicted to be active in nucleus. Is expressed in head; nervous system; pharynx; reproductive system; and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Orthologous to human BRIP1 (BRCA1 interacting helicase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dog-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (15017283..15022990, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein mtd-1 Neighboring gene DNA polymerase epsilon catalytic subunit Neighboring gene Regulator of microtubule dynamics protein 1 Neighboring gene Protein FAM91A1 Neighboring gene ncRNA Neighboring gene MYND-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans. Li X, et al. Nucleic Acids Res, 2024 Sep 9. PMID 39011897, Free PMC Article
    2. A DOG's View of Fanconi Anemia: Insights from C. elegans. Jones M, et al. Anemia, 2012. PMID 22690333, Free PMC Article
    3. FANCJ promotes DNA synthesis through G-quadruplex structures. Castillo Bosch P, et al. EMBO J, 2014 Nov 3. PMID 25193968, Free PMC Article
    4. Poly-G/poly-C tracts in the genomes of Caenorhabditis. Zhao Y, et al. BMC Genomics, 2007 Nov 7. PMID 17986356, Free PMC Article
    5. Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers. Lemmens B, et al. Nat Commun, 2015 Nov 13. PMID 26563448, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans.
      Title: The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans.
    2. Absence of DOG-1 is not only tolerated but also cooperate to achieve long-term population survival.
      Title: Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation.
    3. These data provide evidence that the G4 sequence instability in FANCJ(-/-) cells and Fancj/dog1 deficient C. elegans is caused by replication stalling at G-quadruplexes.
      Title: FANCJ promotes DNA synthesis through G-quadruplex structures.
    4. analysis of the spectrum of mutational events in the absence of DOG-1/FANCJ in Caenorhabditis elegans
      Title: Spectrum of mutational events in the absence of DOG-1/FANCJ in Caenorhabditis elegans.
    5. dog-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.
      Title: DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.
    6. absence of DOG-1 leads to replication fork stalling that can be repaired by deletion-free or deletion-prone mechanisms
      Title: Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair involved in meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of DNA repeat elements IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Helicase ATP-binding domain-containing protein
    NP_493618.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      15017283..15022990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061217.7 → NP_493618.1  Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62217
      Conserved Domains (1) summary
      TIGR00604
      Location:238 → 947
      rad3; DNA repair helicase (rad3)
    Nucleotide Protein
    Heading Accession and Version

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