F47G4.4 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F47G4.4
Official Full Name: WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00009825
Locus tag: CELE_F47G4.4
See related: AllianceGenome:WB:WBGene00009825
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Contributes to microtubule severing ATPase activity. Involved in microtubule depolymerization. Part of katanin complex. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F47G4.4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (14062749..14068803, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Katanin is required for translocation of the meiosis I spindle to the oocyte cortex.
Title: MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F47G4.4 (e-PCR)
- UniSTS:312601

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to microtubule severing ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of katanin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of katanin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD_REPEATS_REGION domain-containing protein

NP_493453.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14062749..14068803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061052.6 → NP_493453.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493453.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XTS1

Conserved Domains (3) summary

COG2319
Location:54 → 317

WD40; WD40 repeat [General function prediction only]

sd00039
Location:56 → 91

7WD40; WD40 repeat [structural motif]

cl02567
Location:54 → 236

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...