ubxn-2 SEP domain-containing protein;UBX domain-containing protein;UBX domain-containing protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubxn-2
Official Full Name: SEP domain-containing protein;UBX domain-containing protein;UBX domain-containing protein 2
Primary source: WormBase:WBGene00022381
Locus tag: CELE_Y94H6A.9
See related: AllianceGenome:WB:WBGene00022381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables K48-linked polyubiquitin modification-dependent protein binding activity and protein kinase binding activity. Involved in several processes, including establishment of mitotic spindle orientation; masculinization of hermaphroditic germ-line; and negative regulation of protein localization to centrosome. Located in nucleus; perinuclear region of cytoplasm; and spindle pole centrosome. Is expressed in several structures, including body wall musculature; gonad; intestine; pharynx; and spermatocyte. Orthologous to several human genes including NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ubxn-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (2720313..2725819, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A
Title: The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in masculinization of hermaphroditic germ-line	IGI Inferred from Genetic Interaction more info	PubMed
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear membrane reassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SEP domain-containing protein;UBX domain-containing protein;UBX domain-containing protein 2

NP_001023590.1

Confirmed by transcript evidence

NP_001360209.1

Partially confirmed by transcript evidence

NP_001368066.1

Confirmed by transcript evidence

NP_001368223.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

2720313..2725819 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028419.5 → NP_001023590.1 UBX domain-containing protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023590.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86DD7, Q9N2W5

Conserved Domains (2) summary

pfam08059
Location:94 → 164

SEP; SEP domain

cl00155
Location:220 → 292

UBQ; Ubiquitin-like proteins
NM_001380105.1 → NP_001368066.1 UBX domain-containing protein 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd01770
Location:116 → 187

UBX_UBXN2; Ubiquitin regulatory domain X (UBX) found in UBX domain-containing proteins UBXN2A, UBXN2B, NSFL1C/UBXN2C, and similar proteins

pfam08059
Location:1 → 56

SEP; SEP domain
NM_001380106.1 → NP_001368223.1 UBX domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PAW3

Conserved Domains (1) summary

cl28922
Location:3 → 37

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
NM_001372754.2 → NP_001360209.1 SEP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBA6

Conserved Domains (1) summary

pfam08059
Location:94 → 164

SEP; SEP domain