sur-6 Serine/threonine-protein phosphatase 2A regulatory subunit sur-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sur-6
Official Full Name: Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
Primary source: WormBase:WBGene00006352
Locus tag: CELE_F26E4.1
See related: AllianceGenome:WB:WBGene00006352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Is expressed in excretory cell; intestine; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to several human genes including PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sur-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (9754122..9757900)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP2A-B55[SUR-6] promotes nuclear envelope breakdown in C. elegans embryos.
Title: PP2A-B55(SUR-6) promotes nuclear envelope breakdown in C. elegans embryos.
Down-regulation of the phosphatase protein phosphatase 2A (PP2A) phosphatase regulatory subunit sur-6/B55 gene resulted in accumulation of exocytic SNARE proteins SNB-1 and SNAP-29 in wild-type and in exoc-8 mutant animals.
Title: par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26E4.1 (e-PCR)
- UniSTS:309961

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase 2A regulatory subunit sur-6

NP_492591.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9754122..9757900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060190.8 → NP_492591.1 Serine/threonine-protein phosphatase 2A regulatory subunit sur-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492591.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDR3

Conserved Domains (3) summary

COG5170
Location:49 → 493

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:69 → 118

7WD40; WD40 repeat [structural motif]

cl02567
Location:174 → 433

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...