rpn-1 26S proteasome non-ATPase regulatory subunit 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpn-1
Official Full Name: 26S proteasome non-ATPase regulatory subunit 2
Primary source: WormBase:WBGene00004458
Locus tag: CELE_T22D1.9
See related: AllianceGenome:WB:WBGene00004458
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable enzyme regulator activity. Involved in nematode larval development. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in nucleus and proteasome storage granule. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpn-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (6906420..6909913, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T22D1.9 (e-PCR)
- UniSTS:310955

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome accessory complex	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info
is_active_in proteasome storage granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 2

NP_501064.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6906420..6909913 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068663.6 → NP_501064.1 26S proteasome non-ATPase regulatory subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501064.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GZH5

Conserved Domains (2) summary

COG5110
Location:23 → 972

RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

pfam01851
Location:783 → 814

PC_rep; Proteasome/cyclosome repeat