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    cisd-3.2 Iron-binding zinc finger CDGSH type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cisd-3.2
    Official Full Name
    Iron-binding zinc finger CDGSH type domain-containing protein
    Primary source
    WormBase:WBGene00022053
    Locus tag
    CELE_Y67D2.3
    See related
    AllianceGenome:WB:WBGene00022053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cisd-3.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (1540493..1543448)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene CP-type G domain-containing protein;Mitochondrial GTPase 1 Neighboring gene ncRNA Neighboring gene N-acetyltransferase 9-like protein Neighboring gene putative ATP-dependent RNA helicase DHX35 homolog Neighboring gene ncRNA Neighboring gene Early ELOngation arrest Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial localized CISD-3.1/CISD-3.2 proteins are required to maintain normal germline structure and function in Caenorhabditis elegans. King SD, et al. PLoS One, 2021. PMID 33544710, Free PMC Article
    2. Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. Boos JR, et al. Adv Redox Res, 2022 Dec. PMID 36533211, Free PMC Article
    3. The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans. King SD, et al. Cell Death Differ, 2019 Jan. PMID 29666474, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by [2Fe-2S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Iron-binding zinc finger CDGSH type domain-containing protein
    NP_497419.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1540493..1543448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065018.9 → NP_497419.1  Iron-binding zinc finger CDGSH type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BKQ9
      Conserved Domains (1) summary
      cl02748
      Location:48 → 81
      zf-CDGSH; Iron-binding zinc finger CDGSH type
    Nucleotide Protein
    Heading Accession and Version

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