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    asp-6 Aspartic protease 6 [ Caenorhabditis elegans ]

    Gene ID: 179209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asp-6
    Official Full Name
    Aspartic protease 6
    Primary source
    WormBase:WBGene00000219
    Locus tag
    CELE_F21F8.7
    See related
    AllianceGenome:WB:WBGene00000219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Located in extracellular space. Is expressed in hypodermal cell; intestine; muscle cell; pharynx; and pseudocoelom. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asp-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (8267511..8268937, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Peptidase A1 domain-containing protein Neighboring gene Peptidase A1 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. Tcherepanova I, et al. J Biol Chem, 2000 Aug 25. PMID 10854422
    2. First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Lochnit G, et al. Biol Chem, 2006 Oct-Nov. PMID 17081123
    3. Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure. Mello LV, et al. BMC Genomics, 2009 Dec 16. PMID 20015380, Free PMC Article
    4. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Florez-McClure ML, et al. Autophagy, 2007 Nov-Dec. PMID 17675890
    5. Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Wong D, et al. Genome Biol, 2007. PMID 17875205, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aspartic protease 6
    NP_505133.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8267511..8268937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072732.10 → NP_505133.1  Aspartic protease 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01530
      Conserved Domains (2) summary
      cd05471
      Location:71 → 385
      pepsin_like; Pepsin-like aspartic proteases, bilobal enzymes that cleave bonds in peptides at acidic pH
      pfam00026
      Location:70 → 385
      Asp; Eukaryotic aspartyl protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01530.1

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