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    pcyt-2.1 IstB_IS21 domain-containing protein;Secreted protein;ethanolamine-phosphate cytidylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 171770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcyt-2.1
    Official Full Name
    IstB_IS21 domain-containing protein;Secreted protein;ethanolamine-phosphate cytidylyltransferase
    Primary source
    WormBase:WBGene00021352
    Locus tag
    CELE_Y37E3.11
    See related
    AllianceGenome:WB:WBGene00021352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ethanolamine-phosphate cytidylyltransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 82. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pcyt-2.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (2078955..2085680)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 2 subunit 1 Neighboring gene Mitochondrial prohibitin complex protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ig-like domain-containing protein Neighboring gene Nuclear pore protein Neighboring gene Uncharacterized protein Neighboring gene Solute carrier family 40 member

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article
    2. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IstB_IS21 domain-containing protein;Secreted protein;ethanolamine-phosphate cytidylyltransferase
    NP_001122537.1
    • Confirmed by transcript evidence
    NP_001293342.1
    • Confirmed by transcript evidence
    NP_001293343.1
    • Confirmed by transcript evidence
    NP_001293344.1
    • Confirmed by transcript evidence
    NP_001293345.1
    • Confirmed by transcript evidence
    NP_001293346.1
    • Confirmed by transcript evidence
    NP_001293347.1
    • Confirmed by transcript evidence
    NP_001293348.1
    • Confirmed by transcript evidence
    NP_490931.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2078955..2085680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129065.2 → NP_001122537.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9D2X7
      Conserved Domains (1) summary
      PTZ00308
      Location:5 → 369
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    2. NM_058530.5 → NP_490931.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BKU2
      Conserved Domains (1) summary
      PTZ00308
      Location:5 → 362
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    3. NM_001306419.2 → NP_001293348.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LPX5
      Conserved Domains (1) summary
      PTZ00308
      Location:5 → 383
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    4. NM_001306413.3 → NP_001293342.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LV72
      Conserved Domains (1) summary
      PTZ00308
      Location:2 → 315
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    5. NM_001306414.3 → NP_001293343.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LPW7
      Conserved Domains (1) summary
      PTZ00308
      Location:2 → 294
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    6. NM_001306415.3 → NP_001293344.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LX84
      Conserved Domains (1) summary
      cd02173
      Location:30 → 184
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)

    7. NM_001306416.3 → NP_001293345.1  IstB_IS21 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5S8
      Conserved Domains (1) summary
      cl00015
      Location:1 → 104
      nt_trans; nucleotidyl transferase superfamily

    8. NM_001306417.3 → NP_001293346.1  Secreted protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M8X2

    9. NM_001306418.1 → NP_001293347.1  IstB_IS21 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LV76
      Conserved Domains (1) summary
      cl00015
      Location:1 → 25
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version

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