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    PLAAT3 phospholipase A and acyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 11145, updated on 9-Dec-2024

    Summary

    Official Symbol
    PLAAT3provided by HGNC
    Official Full Name
    phospholipase A and acyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:17825
    See related
    Ensembl:ENSG00000176485 MIM:613867; AllianceGenome:HGNC:17825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AdPLA; FPLD9; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1
    Summary
    Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PLAAT3 in Genome Data Viewer
    Location:
    11q12.3-q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63574462..63616927, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63563752..63606267, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63341934..63381909, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:63312621-63313820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4871 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3435 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene phospholipase A and acyltransferase 2 Neighboring gene uncharacterized LOC105369335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63368875-63369376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63372619-63373384 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63378198-63378707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63379461-63379961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3437 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438213-63438714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438715-63439214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3441 Neighboring gene reticulon 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A1 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ether lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in organelle disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of adipose tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phospholipase A and acyltransferase 3
    Names
    Ca-independent phospholipase A1/2
    H-rev 107 protein homolog
    HRAS-like suppressor 1
    HRAS-like suppressor 3
    adipose-specific PLA2
    adipose-specific phospholipase A2
    group XVI phospholipase A1/A2
    group XVI phospholipase A2
    phospholipase A/acyltransferase-3
    phospholipase A2 group XVI
    renal carcinoma antigen NY-REN-65
    NP_001121675.1
    NP_009000.2
    XP_011543043.1
    XP_054223515.1
    XP_054223516.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128203.2NP_001121675.1  phospholipase A and acyltransferase 3

      See identical proteins and their annotated locations for NP_001121675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI374456, AI590735, BG719903, CK003948
      Consensus CDS
      CCDS8047.1
      UniProtKB/Swiss-Prot
      B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
      Related
      ENSP00000389124.1, ENST00000415826.3
      Conserved Domains (1) summary
      pfam04970
      Location:19125
      LRAT; Lecithin retinol acyltransferase
    2. NM_007069.3NP_009000.2  phospholipase A and acyltransferase 3

      See identical proteins and their annotated locations for NP_009000.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI374456, AI590735, AK313075, AU099540
      Consensus CDS
      CCDS8047.1
      UniProtKB/Swiss-Prot
      B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1
      Related
      ENSP00000320337.5, ENST00000323646.9
      Conserved Domains (1) summary
      pfam04970
      Location:19125
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63574462..63616927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544741.2XP_011543043.1  phospholipase A and acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_011543043.1

      Conserved Domains (1) summary
      pfam04970
      Location:35140
      LRAT; Lecithin retinol acyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63563752..63606267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367540.1XP_054223515.1  phospholipase A and acyltransferase 3 isoform X1

    2. XM_054367541.1XP_054223516.1  phospholipase A and acyltransferase 3 isoform X2

      UniProtKB/Swiss-Prot
      B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1