U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HNRNPM heterogeneous nuclear ribonucleoprotein M [ Homo sapiens (human) ]

    Gene ID: 4670, updated on 3-Dec-2024

    Summary

    Official Symbol
    HNRNPMprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Mprovided by HGNC
    Primary source
    HGNC:HGNC:5046
    See related
    Ensembl:ENSG00000099783 MIM:160994; AllianceGenome:HGNC:5046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 50.0), colon (RPKM 44.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HNRNPM in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8444975..8489114)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8432898..8476696)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8509859..8553998)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAB11B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10021 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 2878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8477814-8478314 Neighboring gene Sharpr-MPRA regulatory region 12836 Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8488918-8489781 Neighboring gene Sharpr-MPRA regulatory region 689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8563393-8564079 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8570689-8571189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8571229-8571815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8576283-8577173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10030 Neighboring gene zinc finger protein 414

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Cellular biotinylated heterogeneous nuclear ribonucleoprotein M (HNRNPM) is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein M (HNRNPM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPM is increased by RRE PubMed
    Tat tat Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPM gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPM PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp547H118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in paraspeckles IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein M
    Names
    CEA receptor
    N-acetylglucosamine receptor 1
    heterogenous nuclear ribonucleoprotein M4
    hnRNA-binding protein M4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029850.1 RefSeqGene

      Range
      5057..49196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297418.2 → NP_001284347.1  heterogeneous nuclear ribonucleoprotein M isoform c

      See identical proteins and their annotated locations for NP_001284347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA244120, AB209733, CN350481, CN350526, HY007201
      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (5) summary
      TIGR01628
      Location:82 → 236
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12659
      Location:84 → 159
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:519 → 595
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:279 → 418
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
      cl17169
      Location:1 → 27
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_005968.5 → NP_005959.2  heterogeneous nuclear ribonucleoprotein M isoform a

      See identical proteins and their annotated locations for NP_005959.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC000138, CN350526
      Consensus CDS
      CCDS12203.1
      UniProtKB/Swiss-Prot
      P52272, Q15584, Q8WZ44, Q96H56, Q9BWL9, Q9Y492
      UniProtKB/TrEMBL
      Q59ES8
      Related
      ENSP00000325376.2, ENST00000325495.9
      Conserved Domains (5) summary
      pfam11532
      Location:41 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cd12657
      Location:72 → 147
      RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12659
      Location:204 → 279
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:654 → 730
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:414 → 553
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
    3. NM_031203.4 → NP_112480.2  heterogeneous nuclear ribonucleoprotein M isoform b

      See identical proteins and their annotated locations for NP_112480.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      BC008895, BC058893, CN350526, DB478004
      Consensus CDS
      CCDS12204.1
      UniProtKB/TrEMBL
      Q59ES8
      Related
      ENSP00000325732.2, ENST00000348943.7
      Conserved Domains (5) summary
      pfam11532
      Location:41 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cd12657
      Location:72 → 147
      RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12659
      Location:165 → 240
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:615 → 691
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:375 → 514
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      8444975..8489114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272479.3 → XP_005272536.1  heterogeneous nuclear ribonucleoprotein M isoform X2

      See identical proteins and their annotated locations for XP_005272536.1

      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (4) summary
      cd12386
      Location:206 → 279
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:72 → 147
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:636 → 712
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:42 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    2. XM_005272478.4 → XP_005272535.1  heterogeneous nuclear ribonucleoprotein M isoform X1

      See identical proteins and their annotated locations for XP_005272535.1

      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (5) summary
      pfam11532
      Location:41 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cd12657
      Location:72 → 147
      RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12659
      Location:204 → 279
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:639 → 715
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:399 → 538
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
    3. XM_017026823.2 → XP_016882312.1  heterogeneous nuclear ribonucleoprotein M isoform X3

      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (5) summary
      TIGR01628
      Location:60 → 373
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:206 → 279
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:72 → 147
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:621 → 697
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:42 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    4. XM_017026824.2 → XP_016882313.1  heterogeneous nuclear ribonucleoprotein M isoform X5

      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (4) summary
      cd12386
      Location:167 → 240
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:597 → 673
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:42 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cl17169
      Location:72 → 147
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_005272480.3 → XP_005272537.1  heterogeneous nuclear ribonucleoprotein M isoform X4

      See identical proteins and their annotated locations for XP_005272537.1

      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (5) summary
      pfam11532
      Location:41 → 70
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cd12657
      Location:72 → 147
      RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12659
      Location:165 → 240
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:600 → 676
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:360 → 499
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
    6. XM_017026825.2 → XP_016882314.1  heterogeneous nuclear ribonucleoprotein M isoform X6

      UniProtKB/TrEMBL
      Q59ES8
    7. XM_047438860.1 → XP_047294816.1  heterogeneous nuclear ribonucleoprotein M isoform X7

      UniProtKB/TrEMBL
      Q59ES8
    8. XM_017026831.2 → XP_016882320.1  heterogeneous nuclear ribonucleoprotein M isoform X8

      UniProtKB/TrEMBL
      Q7KYM9
    9. XM_017026832.2 → XP_016882321.1  heterogeneous nuclear ribonucleoprotein M isoform X9

    10. XM_047438861.1 → XP_047294817.1  heterogeneous nuclear ribonucleoprotein M isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      8432898..8476696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321059.1 → XP_054177034.1  heterogeneous nuclear ribonucleoprotein M isoform X2

      UniProtKB/TrEMBL
      Q59ES8
    2. XM_054321058.1 → XP_054177033.1  heterogeneous nuclear ribonucleoprotein M isoform X1

      UniProtKB/TrEMBL
      Q59ES8
    3. XM_054321060.1 → XP_054177035.1  heterogeneous nuclear ribonucleoprotein M isoform X3

      UniProtKB/TrEMBL
      Q59ES8
    4. XM_054321062.1 → XP_054177037.1  heterogeneous nuclear ribonucleoprotein M isoform X5

      UniProtKB/TrEMBL
      Q59ES8
    5. XM_054321061.1 → XP_054177036.1  heterogeneous nuclear ribonucleoprotein M isoform X4

      UniProtKB/TrEMBL
      Q59ES8
    6. XM_054321063.1 → XP_054177038.1  heterogeneous nuclear ribonucleoprotein M isoform X6

      UniProtKB/TrEMBL
      Q59ES8
    7. XM_054321064.1 → XP_054177039.1  heterogeneous nuclear ribonucleoprotein M isoform X7

      UniProtKB/TrEMBL
      Q59ES8
    8. XM_054321065.1 → XP_054177040.1  heterogeneous nuclear ribonucleoprotein M isoform X8

      UniProtKB/TrEMBL
      Q7KYM9
    9. XM_054321066.1 → XP_054177041.1  heterogeneous nuclear ribonucleoprotein M isoform X9

    10. XM_054321067.1 → XP_054177042.1  heterogeneous nuclear ribonucleoprotein M isoform X10