MEIS3 Meis homeobox 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MEIS3provided by HGNC
Official Full Name: Meis homeobox 3provided by HGNC
Primary source: HGNC:HGNC:29537
See related: Ensembl:ENSG00000105419 MIM:619443; AllianceGenome:HGNC:29537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRG2
Summary: This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]
Expression: Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (47403124..47422233, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (50228571..50253087, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (47906381..47925490, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt.
Title: Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt.
Findings support a model in which Meis3 is required for neural crest proliferation, migration into, and colonization of the gut such that its loss leads to severe defects in enteric nervous system development.
Title: Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development.
This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
Title: An autoinhibitory effect of the homothorax domain of Meis2.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in eye development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info

General protein information

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Preferred Names: homeobox protein Meis3

Names: Meis1, myeloid ecotropic viral integration site 1 homolog 3; meis1-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051644.1 RefSeqGene

Range

7707..24110

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001009813.3 → NP_001009813.1 homeobox protein Meis3 isoform 2

See identical proteins and their annotated locations for NP_001009813.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses alternate in-frame acceptor splice sites at two internal exon junctions compared to variant 1, which results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.

Source sequence(s)

AL537583, BC069251, CF993984

Consensus CDS

CCDS46132.1

UniProtKB/Swiss-Prot

A8K0S8

Related

ENSP00000388667.2, ENST00000441740.6

Conserved Domains (2) summary

pfam05920
Location:263 → 302

Homeobox_KN; Homeobox KN domain

pfam16493
Location:96 → 162

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001301059.2 → NP_001287988.1 homeobox protein Meis3 isoform 3

See identical proteins and their annotated locations for NP_001287988.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AL537583, BC045741, BI522513, BM783223, CF993984

Consensus CDS

CCDS74406.1

UniProtKB/Swiss-Prot

A8K0S8, A8K1N5, Q6NT73, Q8TC66, Q99687, Q9NPW2

Related

ENSP00000454073.1, ENST00000558555.6

Conserved Domains (2) summary

pfam05920
Location:280 → 319

Homeobox_KN; Homeobox KN domain

pfam16493
Location:96 → 179

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001346148.2 → NP_001333077.1 homeobox protein Meis3 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AC073548

UniProtKB/Swiss-Prot

A8K0S8
NM_020160.3 → NP_064545.1 homeobox protein Meis3 isoform 1

See identical proteins and their annotated locations for NP_064545.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL537583, BC025404, CF993984, DB545063

Consensus CDS

CCDS33064.1

UniProtKB/Swiss-Prot

A8K0S8

Related

ENSP00000453307.1, ENST00000561293.5

Conserved Domains (2) summary

pfam05920
Location:329 → 365

Homeobox_KN; Homeobox KN domain

pfam16493
Location:96 → 179

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

47403124..47422233 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024451615.2 → XP_024307383.1 homeobox protein Meis3 isoform X4

UniProtKB/Swiss-Prot

A8K0S8

Conserved Domains (2) summary

pfam05920
Location:326 → 362

Homeobox_KN; Homeobox KN domain

pfam16493
Location:93 → 176

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_024451616.2 → XP_024307384.1 homeobox protein Meis3 isoform X6

UniProtKB/Swiss-Prot

A8K0S8

UniProtKB/TrEMBL

H3BLU4

Related

ENSP00000333552.4, ENST00000331559.9

Conserved Domains (2) summary

pfam05920
Location:312 → 348

Homeobox_KN; Homeobox KN domain

pfam16493
Location:96 → 162

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_024451617.2 → XP_024307385.1 homeobox protein Meis3 isoform X7

Related

ENST00000561204.5

Conserved Domains (2) summary

pfam05920
Location:197 → 233

Homeobox_KN; Homeobox KN domain

pfam16493
Location:1 → 47

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_017027011.2 → XP_016882500.1 homeobox protein Meis3 isoform X5

UniProtKB/TrEMBL

H0YNA8

Related

ENSP00000453934.1, ENST00000561096.5
XM_024451613.2 → XP_024307381.1 homeobox protein Meis3 isoform X2

Conserved Domains (2) summary

pfam05920
Location:400 → 436

Homeobox_KN; Homeobox KN domain

pfam16493
Location:184 → 250

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_024451612.2 → XP_024307380.1 homeobox protein Meis3 isoform X1

Conserved Domains (2) summary

pfam05920
Location:417 → 453

Homeobox_KN; Homeobox KN domain

pfam16493
Location:184 → 267

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_011527136.4 → XP_011525438.1 homeobox protein Meis3 isoform X3

Conserved Domains (2) summary

pfam05920
Location:351 → 390

Homeobox_KN; Homeobox KN domain

pfam16493
Location:184 → 250

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_047439109.1 → XP_047295065.1 homeobox protein Meis3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

50228571..50253087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321499.1 → XP_054177474.1 homeobox protein Meis3 isoform X4
XM_054321501.1 → XP_054177476.1 homeobox protein Meis3 isoform X6

UniProtKB/TrEMBL

H3BLU4
XM_054321502.1 → XP_054177477.1 homeobox protein Meis3 isoform X7
XM_054321500.1 → XP_054177475.1 homeobox protein Meis3 isoform X5

UniProtKB/TrEMBL

H0YNA8
XM_054321497.1 → XP_054177472.1 homeobox protein Meis3 isoform X2
XM_054321495.1 → XP_054177470.1 homeobox protein Meis3 isoform X1
XM_054321498.1 → XP_054177473.1 homeobox protein Meis3 isoform X3
XM_054321496.1 → XP_054177471.1 homeobox protein Meis3 isoform X1