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    SOCS6 suppressor of cytokine signaling 6 [ Homo sapiens (human) ]

    Gene ID: 9306, updated on 27-Nov-2024

    Summary

    Official Symbol
    SOCS6provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 6provided by HGNC
    Primary source
    HGNC:HGNC:16833
    See related
    Ensembl:ENSG00000170677 MIM:605118; AllianceGenome:HGNC:16833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060
    Summary
    The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in small intestine (RPKM 4.2), colon (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SOCS6 in Genome Data Viewer
    Location:
    18q22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (70289045..70330199)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (70504115..70545262)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (67956281..67997435)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372180 Neighboring gene uncharacterized LOC124904321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:67904225-67904725 Neighboring gene uncharacterized LOC107985158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:67944250-67944750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9540 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:67960199-67960375 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:68004081-68005280 Neighboring gene long intergenic non-protein coding RNA 1909 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:68015472-68016064 Neighboring gene liver cell viability associated lncRNA Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:68024559-68025758 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:68033479-68034190 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:68034191-68034901 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:68051227-68052426 Neighboring gene long intergenic non-protein coding RNA 1910

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    suppressor of cytokine signaling 6
    Names
    STAT induced STAT inhibitor-4
    cytokine-inducible SH2 protein 4
    suppressor of cytokine signaling 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004232.4NP_004223.2  suppressor of cytokine signaling 6

      See identical proteins and their annotated locations for NP_004223.2

      Status: REVIEWED

      Source sequence(s)
      AC023395, BC020082
      Consensus CDS
      CCDS11998.1
      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Related
      ENSP00000381034.3, ENST00000397942.4
      Conserved Domains (2) summary
      cd10387
      Location:373472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      70289045..70330199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026087.2XP_016881576.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Conserved Domains (2) summary
      cd10387
      Location:373472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    2. XM_047437940.1XP_047293896.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
    3. XM_005266783.5XP_005266840.1  suppressor of cytokine signaling 6 isoform X1

      See identical proteins and their annotated locations for XP_005266840.1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Conserved Domains (2) summary
      cd10387
      Location:373472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    4. XM_047437937.1XP_047293893.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
    5. XM_047437941.1XP_047293897.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
    6. XM_047437942.1XP_047293898.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
    7. XM_017026086.2XP_016881575.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Conserved Domains (2) summary
      cd10387
      Location:373472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    8. XM_047437938.1XP_047293894.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Related
      ENSP00000463395.1, ENST00000582322.1
    9. XM_047437939.1XP_047293895.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      70504115..70545262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016387.1: Suppressed sequence

      Description
      NM_016387.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.