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    ARMCX4 armadillo repeat containing X-linked 4 [ Homo sapiens (human) ]

    Gene ID: 100131755, updated on 27-Nov-2024

    Summary

    Official Symbol
    ARMCX4provided by HGNC
    Official Full Name
    armadillo repeat containing X-linked 4provided by HGNC
    Primary source
    HGNC:HGNC:28615
    See related
    Ensembl:ENSG00000196440 MIM:301046; AllianceGenome:HGNC:28615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASP4; CXorf35
    Summary
    The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 2.9) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ARMCX4 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101418278..101535988)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99862393..99980621)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100673266..100790975)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RPL36A-HNRNPH2 readthrough Neighboring gene heterogeneous nuclear ribonucleoprotein H2 Neighboring gene galactosidase alpha Neighboring gene peptidylprolyl isomerase A pseudogene 90 Neighboring gene PRKCI pseudogene 1 Neighboring gene armadillo repeat containing X-linked 1 Neighboring gene armadillo repeat containing X-linked 7, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ARMCX1

    Clone Names

    • FLJ39636, FLJ43051, FLJ45041, MGC40053, DKFZp586N0819, DKFZp781M0415

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    armadillo repeat-containing X-linked protein 4
    Names
    armadillo repeat containing, X-linked 4 pseudogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017196.3 RefSeqGene

      Range
      72179..82530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256155.3NP_001243084.2  armadillo repeat-containing X-linked protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents a protein-coding variant and contains a long, terminal coding exon instead of extensive splicing found in variant 2. The full extent of the 5' UTR has not been determined.
      Source sequence(s)
      KF459252, Z68873
      Consensus CDS
      CCDS59170.1
      UniProtKB/Swiss-Prot
      A8K928, B3KXA4, F8W8Y7, Q5H9K8, Q5H9R4, Q8N8D6
      Related
      ENSP00000404304.3, ENST00000423738.5
      Conserved Domains (3) summary
      PRK07735
      Location:84320
      PRK07735; NADH-quinone oxidoreductase subunit C
      pfam04826
      Location:20322283
      Arm_2; Armadillo-like
      pfam06682
      Location:15141646
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis

    RNA

    1. NR_028407.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC234775, AL035422, Z68873
    2. NR_045861.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC234775, Z68873
    3. NR_045862.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC234775, Z68873
    4. NR_045863.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      Z68873
      Related
      ENST00000445416.5
    5. NR_045864.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC234775, Z68873

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      101418278..101535988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99862393..99980621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152583.2: Suppressed sequence

      Description
      NM_152583.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.