FCRL4 Fc receptor like 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCRL4provided by HGNC
Official Full Name: Fc receptor like 4provided by HGNC
Primary source: HGNC:HGNC:18507
See related: Ensembl:ENSG00000163518 MIM:605876; AllianceGenome:HGNC:18507
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FCRH4; IGFP2; IRTA1; CD307d
Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Expression: Biased expression in lymph node (RPKM 2.4), appendix (RPKM 2.3) and 5 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q23.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (157573747..157598085, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (156710808..156735121, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (157543537..157567875, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.
Title: IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.
The Multiple Roles of B Cells in the Pathogenesis of Sjogren's Syndrome.
Title: The Multiple Roles of B Cells in the Pathogenesis of Sjögren's Syndrome.
Fc receptor-like 4 and 5 define human atypical memory B cells.
Title: Fc receptor-like 4 and 5 define human atypical memory B cells.
Gene expression profiling of epithelium-associated FcRL4(+) B cells in primary Sjogren's syndrome reveals a pathogenic signature.
Title: Gene expression profiling of epithelium-associated FcRL4(+) B cells in primary Sjögren's syndrome reveals a pathogenic signature.
IRTA1 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs).
Title: IRTA1 and MNDA Expression in Marginal Zone Lymphoma: Utility in Differential Diagnosis and Implications for Classification.
Abs with reactivity to commensal microbiota were enriched in FCRL4(+) cells.
Title: Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens.
We conclude that these activated B cells are a component of the local autoimmune response, and through their RANKL expression, can contribute to joint destruction. Furthermore, their expression of FcRL4 and their enrichment in the IgA isotype points towards a potential role for these cells in the link between mucosal and joint inflammation.
Title: B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis.
intraepithelial FcRL4(+) B-cells are present in the salivary glands of pSS patients. These cells are likely involved in the epithelial changes seen in pSS. Their enrichment in parotid glands may explain why MALT lymphomas in pSS patients preferentially develop at this specific location.
Title: FcRL4(+) B-cells in salivary glands of primary Sjögren's syndrome patients.
Commercially available IRTA1 antibody can immunohistochemically distinguish MALT lymphoma from other low-grade B-cell lymphomas.
Title: Immunohistochemical analysis of the novel marginal zone B-cell marker IRTA1 in malignant lymphoma.
decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to rheumatoid arthritis inflammatory processes.
Title: Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Treatment of B cells with HIV-1 gp120 upregulates the expression of FCRL4 and limits the proliferative expansion of B cells in an integrin alpha 4/beta 7-dependent manner	PubMed
	env	HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL009663 (e-PCR)
- UniSTS:57413

D1S2118 (e-PCR)
- UniSTS:23896

NoName (e-PCR)
- UniSTS:485840

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Fc receptor-like protein 4

Names: IFGP family protein 2; fc receptor homolog 4; fcR-like protein 4; hIFGP2; immune receptor translocation-associated protein 1; immunoglobulin superfamily Fc receptor, gp42; immunoglobulin superfamily receptor translocation associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031282.3 → NP_112572.1 Fc receptor-like protein 4 precursor

See identical proteins and their annotated locations for NP_112572.1

Status: REVIEWED

Source sequence(s)

AF343659, AF343661, AL135929

Consensus CDS

CCDS1166.1

UniProtKB/Swiss-Prot

Q96PJ3, Q96PJ5, Q96RE0

Related

ENSP00000271532.1, ENST00000271532.2

Conserved Domains (4) summary

cd05752
Location:23 → 100

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:295 → 377

IG_like; Immunoglobulin like

pfam13895
Location:193 → 281

Ig_2; Immunoglobulin domain

cd05753
Location:105 → 188

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

157573747..157598085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510034.2 → XP_011508336.1 Fc receptor-like protein 4 isoform X1

Conserved Domains (5) summary

cd05752
Location:22 → 99

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:294 → 376

IG_like; Immunoglobulin like

pfam00047
Location:301 → 369

ig; Immunoglobulin domain

pfam13927
Location:192 → 264

Ig_3; Immunoglobulin domain

cl11960
Location:104 → 170

Ig; Immunoglobulin domain