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    SRA1 steroid receptor RNA activator 1 [ Homo sapiens (human) ]

    Gene ID: 10011, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SRA1provided by HGNC
    Official Full Name
    steroid receptor RNA activator 1provided by HGNC
    Primary source
    HGNC:HGNC:11281
    See related
    Ensembl:ENSG00000213523 MIM:603819; AllianceGenome:HGNC:11281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRA; SRAP; STRAA1; pp7684
    Summary
    Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in adrenal (RPKM 15.0), testis (RPKM 12.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRA1 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140550067..140558093, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141075497..141083524, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139929652..139937678, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ANKHD1-EIF4EBP3 readthrough Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene uncharacterized LOC124901194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139926194-139926902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139926903-139927609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139927610-139928317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139936291-139937112 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:139944009-139944615 Neighboring gene uncharacterized LOC131768270 Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene microRNA 6831 Neighboring gene solute carrier family 35 member A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges. Colley SM, et al. Biochimie, 2011 Nov. PMID 21807064
    2. LncRNA SRA deregulation contributes to the development of atherosclerosis by causing dysfunction of endothelial cells through repressing the expression of adipose triglyceride lipase. Yang S, et al. Mol Med Rep, 2018 Dec. PMID 30272285
    3. Long non-coding RNA, steroid receptor RNA activator (SRA), induces tumor proliferation and invasion through the NOTCH pathway in cervical cancer cell lines. Eoh KJ, et al. Oncol Rep, 2017 Dec. PMID 29039612, Free PMC Article
    4. Decreased expression of LncRNA SRA1 in hepatocellular carcinoma and its clinical significance. Luo P, et al. Cancer Biomark, 2017. PMID 28085012
    5. Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis. Lin K, et al. Reprod Sci, 2017 Jun. PMID 27694140

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
      Title: Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
    2. Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
      Title: Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
    3. Steroid Receptor Coactivator-1 (SRC-1) Promoted Cell Metastasis of Gastric Cancer via VEGFC Activator by NF-kappaB.
      Title: Steroid Receptor Coactivator-1 (SRC-1) Promoted Cell Metastasis of Gastric Cancer via VEGFC Activator by NF-κB.
    4. Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor RNA activator as new indicators of metabolic syndrome.
      Title: Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor RNA activator as new indicators of metabolic syndrome.
    5. Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
      Title: Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
    6. LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition.
      Title: LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition.
    7. Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation.
      Title: Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation.
    8. Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway.
      Title: Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway.
    9. Long, Noncoding RNA SRA Induces Apoptosis of beta-Cells by Promoting the IRAK1/LDHA/Lactate Pathway.
      Title: Long, Noncoding RNA SRA Induces Apoptosis of β-Cells by Promoting the IRAK1/LDHA/Lactate Pathway.
    10. Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.
      Title: Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC87674

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables steroid receptor RNA activator RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid receptor RNA activator RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    NOT part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    steroid receptor RNA activator 1
    Names
    lncRNA SRA
    steroid receptor RNA activator 1 (complexes with NCOA1)
    steroid receptor RNA activator protein
    steroid receptor coactivator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031847.1 RefSeqGene

      Range
      5621..13026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035235.4 → NP_001030312.3  steroid receptor RNA activator 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC011399, BC040043
      Consensus CDS
      CCDS34245.2
      UniProtKB/Swiss-Prot
      Q6NVU9, Q8IXM1, Q9HD13, Q9HD14, Q9HD15
      UniProtKB/TrEMBL
      B3KNT3
      Related
      ENSP00000337513.6, ENST00000336283.9
      Conserved Domains (1) summary
      pfam07304
      Location:71 → 207
      SRA1; Steroid receptor RNA activator (SRA1)

    2. NM_001253764.2 → NP_001240693.1  steroid receptor RNA activator 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) retains a segment in the 5' coding region and lacks a downstream coding exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct segment in the N-terminal region, compared to isoform 1.
      Source sequence(s)
      AC011399, BC067895, BQ052761, BU553214
      Conserved Domains (1) summary
      pfam07304
      Location:103 → 191
      SRA1; Steroid receptor RNA activator (SRA1)

    RNA

    1. NR_045586.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF318361, AI140060, BC040043, BQ052761, DQ286291

    2. NR_045587.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) retains a segment in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011399, BC040043, BC067895, BQ052761, DA311407
      Related
      ENST00000602775.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      140550067..140558093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      141075497..141083524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HD15.2 GenPept UniProtKB/Swiss-Prot:Q9HD15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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