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    ZHX1 zinc fingers and homeoboxes 1 [ Homo sapiens (human) ]

    Gene ID: 11244, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZHX1provided by HGNC
    Official Full Name
    zinc fingers and homeoboxes 1provided by HGNC
    Primary source
    HGNC:HGNC:12871
    See related
    Ensembl:ENSG00000165156 MIM:604764; AllianceGenome:HGNC:12871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.7), esophagus (RPKM 16.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZHX1 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123248456..123275541, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124379593..124406678, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124260696..124287781, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene microRNA 4663 Neighboring gene chromosome 8 open reading frame 76 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:124253403-124253903 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27870 Neighboring gene tRNA-Phe (anticodon GAA) 12-1 Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U6 small nuclear 628, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:124285783-124286150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27871 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1385 Neighboring gene ATPase family AAA domain containing 2 Neighboring gene RNA, U6 small nuclear 875, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ZHX1-C8orf76

    Readthrough gene: ZHX1-C8orf76, Included gene: C8orf76

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc fingers and homeoboxes protein 1
    Names
    zinc finger and homeodomain protein 1
    zinc fingers and homeobox 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017926.3NP_001017926.1  zinc fingers and homeoboxes protein 1

      See identical proteins and their annotated locations for NP_001017926.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF106862, AK025236, BC040481, CA776642, CN352595
      Consensus CDS
      CCDS6342.1
      UniProtKB/Swiss-Prot
      Q8IWD8, Q9UKY1
      UniProtKB/TrEMBL
      A8K0G7
      Related
      ENSP00000297857.2, ENST00000297857.3
      Conserved Domains (3) summary
      smart00389
      Location:665716
      HOX; Homeodomain
      cd00086
      Location:468523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785821
      Homez; Homeodomain leucine-zipper encoding, Homez
    2. NM_007222.5NP_009153.3  zinc fingers and homeoboxes protein 1

      See identical proteins and their annotated locations for NP_009153.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF195766, AK025236, BC040481, CA776642, DA238313
      Consensus CDS
      CCDS6342.1
      UniProtKB/Swiss-Prot
      Q8IWD8, Q9UKY1
      UniProtKB/TrEMBL
      A8K0G7
      Related
      ENSP00000378938.2, ENST00000395571.8
      Conserved Domains (3) summary
      smart00389
      Location:665716
      HOX; Homeodomain
      cd00086
      Location:468523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785821
      Homez; Homeodomain leucine-zipper encoding, Homez

    RNA

    1. NR_037873.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the downstream ORF, as found in variant 1. Translation of the upstream ORF would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF106862, AK025236, AK289532, BC040481, CA776642
    2. NR_037874.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal coding exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region, as found in variant 1.
      Source sequence(s)
      AK025236, AK094451, BC040481, CA776642, DA238313

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      123248456..123275541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      124379593..124406678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)