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    SELENBP1 selenium binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 8991, updated on 27-Nov-2024

    Summary

    Official Symbol
    SELENBP1provided by HGNC
    Official Full Name
    selenium binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10719
    See related
    Ensembl:ENSG00000143416 MIM:604188; AllianceGenome:HGNC:10719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTO; LPSB; SP56; hSBP; EHMTO; SBP56; HEL-S-134P
    Summary
    This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
    Expression
    Broad expression in colon (RPKM 232.0), lung (RPKM 124.7) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SELENBP1 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151364304..151372705, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150487989..150496432, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151336780..151345181, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 444, pseudogene Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene Sharpr-MPRA regulatory region 1421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151299400-151300324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151315395-151315895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1718 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:151318990-151320189 Neighboring gene MPRA-validated peak412 silencer Neighboring gene RFX5 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:151332077-151332231 Neighboring gene regulatory factor X5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151342446-151343117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151343118-151343788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151344535-151345118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151345119-151345702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151371406-151372128 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151372129-151372850 Neighboring gene proteasome 20S subunit beta 4 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene RNY4 pseudogene 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Extraoral halitosis due to methanethiol oxidase deficiency
    MedGen: C4748387 OMIM: 618148 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13813

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methanethiol oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables selenium binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    methanethiol oxidase
    Names
    56 kDa selenium-binding protein
    epididymis secretory sperm binding protein Li 134P
    NP_001245217.1
    NP_001245218.1
    NP_003935.2
    XP_047289532.1
    XP_054195462.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258288.2NP_001245217.1  methanethiol oxidase isoform 2

      See identical proteins and their annotated locations for NP_001245217.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK303815, BQ045424, DB288439
      Consensus CDS
      CCDS58027.1
      UniProtKB/Swiss-Prot
      Q13228
      Related
      ENSP00000413960.3, ENST00000447402.7
      Conserved Domains (1) summary
      pfam05694
      Location:7410
      SBP56; 56kDa selenium binding protein (SBP56)
    2. NM_001258289.2NP_001245218.1  methanethiol oxidase isoform 3

      See identical proteins and their annotated locations for NP_001245218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK296661, BQ045424, CR456852, DB288439
      Consensus CDS
      CCDS60266.1
      UniProtKB/Swiss-Prot
      Q13228
      Related
      ENSP00000397261.2, ENST00000426705.6
      Conserved Domains (1) summary
      pfam05694
      Location:49514
      SBP56; 56kDa selenium binding protein (SBP56)
    3. NM_003944.4NP_003935.2  methanethiol oxidase isoform 1

      See identical proteins and their annotated locations for NP_003935.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC009084, DB288439
      Consensus CDS
      CCDS995.1
      UniProtKB/Swiss-Prot
      A6NML9, A6PVW9, B2RDR3, B4DKP6, B4E1F3, Q13228, Q49AQ8, Q96GX7
      UniProtKB/TrEMBL
      V9HWG1
      Related
      ENSP00000357861.5, ENST00000368868.10
      Conserved Domains (1) summary
      pfam05694
      Location:7472
      SBP56; 56kDa selenium binding protein (SBP56)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151364304..151372705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433576.1XP_047289532.1  methanethiol oxidase isoform X1

    RNA

    1. XR_007064849.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150487989..150496432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339487.1XP_054195462.1  methanethiol oxidase isoform X1

    RNA

    1. XR_008486201.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032183.1: Suppressed sequence

      Description
      NM_032183.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.