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    DAGLA diacylglycerol lipase alpha [ Homo sapiens (human) ]

    Gene ID: 747, updated on 9-Dec-2024

    Summary

    Official Symbol
    DAGLAprovided by HGNC
    Official Full Name
    diacylglycerol lipase alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1165
    See related
    Ensembl:ENSG00000134780 MIM:614015; AllianceGenome:HGNC:1165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOC2; NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)
    Summary
    This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
    Expression
    Broad expression in brain (RPKM 6.7), colon (RPKM 2.0) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DAGLA in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61680391..61747001)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61669309..61735921)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61447863..61514473)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61355975-61356553 Neighboring gene uncharacterized LOC101927495 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61366831-61367498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61368167-61368834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61393636-61394198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61394199-61394759 Neighboring gene Sharpr-MPRA regulatory region 3465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61396115-61397096 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61406067-61406567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61406607-61407134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61408188-61408713 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:61430561-61431253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61450060-61450734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61450735-61451408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61457781-61458312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61458313-61458844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61462250-61462775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61462776-61463302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61463303-61463829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61465411-61465936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61465937-61466463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61466990-61467516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61467517-61468042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61468570-61469095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61482486-61483272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61483273-61484058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61484845-61485630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61485631-61486417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61486418-61487203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61487991-61488775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61507907-61508480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61514637-61515498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61516359-61517220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3398 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:61523524-61524723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61524877-61525520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61528511-61529267 Neighboring gene MYRF antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61535574-61536150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61536151-61536726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4800 Neighboring gene myelin regulatory factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61546818-61547486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61548157-61548825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61552558-61553302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61553303-61554047 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:61559319-61560296 and GRCh37_chr11:61560297-61561272 Neighboring gene transmembrane protein 258 Neighboring gene microRNA 611

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipoprotein lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoacylglycerol lipase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in arachidonate metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in cannabinoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diacylglycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diacylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in diacylglycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde trans-synaptic signaling by endocannabinoid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde trans-synaptic signaling by endocannabinoid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde trans-synaptic signaling by endocannabinoid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    diacylglycerol lipase-alpha
    Names
    DAGL-alpha
    DGL-alpha
    neural stem cell-derived dendrite regulator
    sn1-specific diacylglycerol lipase alpha
    NP_006124.1
    XP_047283496.1
    XP_047283497.1
    XP_047283498.1
    XP_047283499.1
    XP_047283500.1
    XP_047283501.1
    XP_054225827.1
    XP_054225828.1
    XP_054225829.1
    XP_054225830.1
    XP_054225831.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006133.3NP_006124.1  diacylglycerol lipase-alpha

      Status: REVIEWED

      Source sequence(s)
      AP002380, BC150176
      Consensus CDS
      CCDS31578.1
      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
      Related
      ENSP00000257215.5, ENST00000257215.10
      Conserved Domains (1) summary
      cd00519
      Location:288529
      Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      61680391..61747001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427544.1XP_047283500.1  diacylglycerol lipase-alpha isoform X2

    2. XM_047427543.1XP_047283499.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    3. XM_047427541.1XP_047283497.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    4. XM_047427542.1XP_047283498.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    5. XM_047427540.1XP_047283496.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    6. XM_047427545.1XP_047283501.1  diacylglycerol lipase-alpha isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      61669309..61735921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369855.1XP_054225830.1  diacylglycerol lipase-alpha isoform X2

    2. XM_054369854.1XP_054225829.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    3. XM_054369853.1XP_054225828.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    4. XM_054369852.1XP_054225827.1  diacylglycerol lipase-alpha isoform X1

      UniProtKB/Swiss-Prot
      A0A024R517, A7E233, Q6WQJ0, Q9Y4D2
    5. XM_054369856.1XP_054225831.1  diacylglycerol lipase-alpha isoform X3