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    EIF1 eukaryotic translation initiation factor 1 [ Homo sapiens (human) ]

    Gene ID: 10209, updated on 9-Dec-2024

    Summary

    Official Symbol
    EIF1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 1provided by HGNC
    Primary source
    HGNC:HGNC:3249
    See related
    Ensembl:ENSG00000173812 MIM:619901; AllianceGenome:HGNC:3249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A121; ISO1; SUI1; EIF-1; EIF1A
    Summary
    Enables ribosomal small subunit binding activity and translation initiation factor activity. Involved in regulation of translational initiation and translational initiation. Located in cytoplasm and nucleus. Part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 681.9), fat (RPKM 274.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See EIF1 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41688885..41692668)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42545340..42549123)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39845137..39848920)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 42, pseudogene Neighboring gene uncharacterized LOC124904004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39803627-39804502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39809802-39810500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39810501-39811197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39816537-39817036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39821445-39821964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39821965-39822482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8497 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39844838-39845746 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39845747-39846655 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39861304-39862096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:39864421-39864948 Neighboring gene Sharpr-MPRA regulatory region 1334 Neighboring gene RNA, 5S ribosomal pseudogene 442 Neighboring gene gastrin Neighboring gene huntingtin associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic 43S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic 48S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of multi-eIF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 1
    Names
    protein translation factor SUI1 homolog
    sui1iso1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005801.4NP_005792.1  eukaryotic translation initiation factor 1

      See identical proteins and their annotated locations for NP_005792.1

      Status: VALIDATED

      Source sequence(s)
      AA159721, AC130686, BC005118, BU165055
      Consensus CDS
      CCDS11403.1
      UniProtKB/Swiss-Prot
      P41567, Q9UNQ9
      UniProtKB/TrEMBL
      K7EM18, Q6IAV3
      Related
      ENSP00000419449.1, ENST00000469257.2
      Conserved Domains (1) summary
      cl00229
      Location:3113
      eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41688885..41692668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42545340..42549123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)