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    FAM168B family with sequence similarity 168 member B [ Homo sapiens (human) ]

    Gene ID: 130074, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FAM168Bprovided by HGNC
    Official Full Name
    family with sequence similarity 168 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:27016
    See related
    Ensembl:ENSG00000152102 MIM:620078; AllianceGenome:HGNC:27016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MANI
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 37.0), fat (RPKM 23.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM168B in Genome Data Viewer
    Location:
    2q21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (131047876..131093460, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (131482169..131527429, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131805449..131851033, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:131706954-131707281 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:131724236-131724855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:131743536-131744354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:131799328-131800200 Neighboring gene small integral membrane protein 39 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11964 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:131855480-131855651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:131856285-131856785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:131871473-131872062 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16533 Neighboring gene NEK2 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Livebearing or egg-laying mammals: 27 decisive nucleotides of FAM168. Pramanik S, et al. Biosci Trends, 2017 May 23. PMID 28381702
    2. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
    3. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Gallardo-Vara E, et al. Cells, 2019 Sep 13. PMID 31540324, Free PMC Article
    4. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. Chen W, et al. Breast Cancer Res Treat, 2023 Oct. PMID 37433992, Free PMC Article
    5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC87527

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myelin-associated neurite-outgrowth inhibitor
    Names
    protein FAM168B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009993.4 → NP_001009993.2  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      BC110642, CN418443, DB453209
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Related
      ENSP00000374565.3, ENST00000389915.4
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. NM_001321743.1 → NP_001308672.1  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC009477
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. NM_001321744.1 → NP_001308673.1  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC009477
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    4. NM_001321745.1 → NP_001308674.1  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC009477
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    5. NM_001321746.2 → NP_001308675.1  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC009477, BC110642, CN418443
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Related
      ENSP00000387051.1, ENST00000409185.5
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    6. NM_001321747.2 → NP_001308676.1  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC009477
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    7. NM_001321748.2 → NP_001308677.1  myelin-associated neurite-outgrowth inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC009477
      Consensus CDS
      CCDS42755.1
      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      131047876..131093460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443337.1 → XP_047299293.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    2. XM_047443336.1 → XP_047299292.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    3. XM_017003327.2 → XP_016858816.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 195
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    4. XM_047443338.1 → XP_047299294.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    5. XM_047443339.1 → XP_047299295.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    6. XM_011510594.4 → XP_011508896.1  myelin-associated neurite-outgrowth inhibitor isoform X2

      Conserved Domains (1) summary
      pfam14944
      Location:24 → 168
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      131482169..131527429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340506.1 → XP_054196481.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    2. XM_054340505.1 → XP_054196480.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    3. XM_054340504.1 → XP_054196479.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    4. XM_054340508.1 → XP_054196483.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    5. XM_054340507.1 → XP_054196482.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      UniProtKB/Swiss-Prot
      A1KXE4, Q2TAZ6, Q6NZ40

    6. XM_054340509.1 → XP_054196484.1  myelin-associated neurite-outgrowth inhibitor isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1KXE4.1 GenPept UniProtKB/Swiss-Prot:A1KXE4

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