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    KCNA10 potassium voltage-gated channel subfamily A member 10 [ Homo sapiens (human) ]

    Gene ID: 3744, updated on 9-Dec-2024

    Summary

    Official Symbol
    KCNA10provided by HGNC
    Official Full Name
    potassium voltage-gated channel subfamily A member 10provided by HGNC
    Primary source
    HGNC:HGNC:6219
    See related
    Ensembl:ENSG00000143105 MIM:602420; AllianceGenome:HGNC:6219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Kcn1; Kv1.8
    Summary
    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See KCNA10 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110517217..110519175, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110532257..110534215, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111059839..111061797, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378898 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:111019910-111020410 and GRCh37_chr1:111020411-111020911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:111025901-111026479 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:111036419-111037385 Neighboring gene CYMP antisense RNA 1 Neighboring gene chymosin, pseudogene Neighboring gene uncharacterized LOC124904292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1175 Neighboring gene potassium voltage-gated channel subfamily A member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1472

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 10
    Names
    cyclic GMP gated potassium channel
    potassium channel, voltage gated shaker related subfamily A, member 10
    potassium voltage-gated channel, shaker-related subfamily, member 10
    voltage-gated potassium channel subunit Kv1.8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005549.2NP_005540.1  potassium voltage-gated channel subfamily A member 10

      See identical proteins and their annotated locations for NP_005540.1

      Status: REVIEWED

      Source sequence(s)
      AL358215
      Consensus CDS
      CCDS826.1
      UniProtKB/Swiss-Prot
      Q16322
      Related
      ENSP00000358786.2, ENST00000369771.4
      Conserved Domains (2) summary
      pfam00520
      Location:255467
      Ion_trans; Ion transport protein
      pfam02214
      Location:88179
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      110517217..110519175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      110532257..110534215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)