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    VOPP1 VOPP1 WW domain binding protein [ Homo sapiens (human) ]

    Gene ID: 81552, updated on 27-Nov-2024

    Summary

    Official Symbol
    VOPP1provided by HGNC
    Official Full Name
    VOPP1 WW domain binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:34518
    See related
    Ensembl:ENSG00000154978 MIM:611915; AllianceGenome:HGNC:34518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ECOP; GASP; WBP1L2
    Summary
    Enables enzyme binding activity. Located in cytoplasmic vesicle membrane; late endosome; and lysosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 19.1), appendix (RPKM 14.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See VOPP1 in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (55434964..55572502, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (55594635..55732784, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (55538301..55640195, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA exonuclease 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26014 Neighboring gene MPRA-validated peak6524 silencer Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:55470127-55471114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55495178-55495682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55495683-55496185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55507999-55508825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55535735-55536236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55540666-55541332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55545601-55546151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55556042-55556542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:55560767-55561966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55579955-55580476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55580477-55580998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55584685-55585190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55592347-55592848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26033 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:55606949-55607581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26035 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55622524-55623470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18189 Neighboring gene Sharpr-MPRA regulatory region 1113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26041 Neighboring gene VOPP1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55661073-55661572 Neighboring gene CDC42 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20532, DKFZp564K0822

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WW domain binding protein VOPP1
    Names
    EGFR-coamplified and overexpressed protein
    Glioblastoma-amplified secreted protein
    VOPP1, WBP1/VOPP1 family member
    hypothetical protein DKFZp564K0822
    putative NF-kappa-B-activating protein 055N
    vesicular, overexpressed in cancer, prosurvival protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284282.2NP_001271211.1  WW domain binding protein VOPP1 isoform 2

      See identical proteins and their annotated locations for NP_001271211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073347, AK309288, HY076549
      Consensus CDS
      CCDS64656.1
      UniProtKB/Swiss-Prot
      Q96AW1
      Related
      ENSP00000393210.1, ENST00000418904.5
      Conserved Domains (1) summary
      cl28929
      Location:88146
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
    2. NM_001284283.2NP_001271212.1  WW domain binding protein VOPP1 isoform 3

      See identical proteins and their annotated locations for NP_001271212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073347, AK315882, DA814621, HY076549
      Consensus CDS
      CCDS64655.1
      UniProtKB/Swiss-Prot
      Q96AW1
      Related
      ENSP00000486983.1, ENST00000625836.2
      Conserved Domains (1) summary
      PRK13729
      Location:102160
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    3. NM_001284284.1NP_001271213.1  WW domain binding protein VOPP1 isoform 4

      See identical proteins and their annotated locations for NP_001271213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073347, AK092992, HY073578, HY076549
      Consensus CDS
      CCDS64654.1
      UniProtKB/Swiss-Prot
      Q96AW1
      Related
      ENSP00000415230.1, ENST00000433959.5
      Conserved Domains (1) summary
      pfam06679
      Location:81124
      DUF1180; Protein of unknown function (DUF1180)
    4. NM_001321242.1NP_001308171.1  WW domain binding protein VOPP1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC073237, AC073347, DA991268, HY076549
    5. NM_001321243.2NP_001308172.1  WW domain binding protein VOPP1 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC073347, DB475432, HY057980, HY076549
    6. NM_001321244.2NP_001308173.1  WW domain binding protein VOPP1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC073347, AC099681, DA732543, DB496308, HY076549
      Consensus CDS
      CCDS83187.1
      UniProtKB/TrEMBL
      C9JVH1
      Related
      ENSP00000407356.1, ENST00000427700.1
      Conserved Domains (1) summary
      PRK13729
      Location:103161
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    7. NM_001321246.2NP_001308175.1  WW domain binding protein VOPP1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC073347, DA257111, DB475432, HY076549
      Conserved Domains (1) summary
      PRK13729
      Location:79137
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    8. NM_001321247.2NP_001308176.1  WW domain binding protein VOPP1 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC073347, BI597655, DB475432, HY076549
    9. NM_001321248.2NP_001308177.1  WW domain binding protein VOPP1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC073347, DA530391, HY076549
      Consensus CDS
      CCDS83186.1
      UniProtKB/TrEMBL
      C9J827, C9JIM1
      Related
      ENSP00000411447.1, ENST00000454227.5
      Conserved Domains (1) summary
      PRK13729
      Location:42100
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    10. NM_001321249.2NP_001308178.1  WW domain binding protein VOPP1 isoform 11 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
      Source sequence(s)
      AC073347, HY032103, HY076549
    11. NM_001321250.2NP_001308179.1  WW domain binding protein VOPP1 isoform 11 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
      Source sequence(s)
      AC073347, AK090825, HY076549
    12. NM_001321251.1NP_001308180.1  WW domain binding protein VOPP1 isoform 11 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
      Source sequence(s)
      AC073237, AC073347, DA772419, HY076549
    13. NM_030796.5NP_110423.3  WW domain binding protein VOPP1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_110423.3

      Status: VALIDATED

      Source sequence(s)
      AC073347, AK225755, DB496308, HY076549
      Consensus CDS
      CCDS47588.1
      UniProtKB/Swiss-Prot
      B0AZU1, B2RAT4, B3KS72, C9JWR3, Q6FIE3, Q8NBN8, Q96AW1, Q96RE5, Q9H0W4
      Related
      ENSP00000285279.5, ENST00000285279.10
      Conserved Domains (1) summary
      cl28929
      Location:105163
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      55434964..55572502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515539.2XP_011513841.1  WW domain binding protein VOPP1 isoform X1

    2. XM_011515546.3XP_011513848.1  WW domain binding protein VOPP1 isoform X4

    3. XM_011515540.3XP_011513842.1  WW domain binding protein VOPP1 isoform X2

    4. XM_011515541.3XP_011513843.1  WW domain binding protein VOPP1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      55594635..55732784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359084.1XP_054215059.1  WW domain binding protein VOPP1 isoform X1

    2. XM_054359087.1XP_054215062.1  WW domain binding protein VOPP1 isoform X4

    3. XM_054359085.1XP_054215060.1  WW domain binding protein VOPP1 isoform X2

    4. XM_054359086.1XP_054215061.1  WW domain binding protein VOPP1 isoform X3