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    KHSRP KH-type splicing regulatory protein [ Homo sapiens (human) ]

    Gene ID: 8570, updated on 9-Dec-2024

    Summary

    Official Symbol
    KHSRPprovided by HGNC
    Official Full Name
    KH-type splicing regulatory proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6316
    See related
    Ensembl:ENSG00000088247 MIM:603445; AllianceGenome:HGNC:6316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p75; FBP2; KSRP; FUBP2
    Summary
    The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
    Expression
    Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KHSRP in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6413102..6424811, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6401987..6413694, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6413113..6424822, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene microRNA 6790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6411708-6412532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6412533-6413357 Neighboring gene microRNA 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13824 Neighboring gene solute carrier family 25 member 41 Neighboring gene solute carrier family 25 member 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6464149-6464690 Neighboring gene DENN domain containing 1C Neighboring gene crumbs cell polarity complex component 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify KH-type splicing regulatory protein (KHSRP; FUBP2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of KH-type splicing regulatory protein (KHSRP, FUBP2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC99676

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone EXP
    Inferred from Experiment
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    far upstream element-binding protein 2
    Names
    FUSE-binding protein 2
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366299.1NP_001353228.1  far upstream element-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC011491, AC011539
      Consensus CDS
      CCDS92499.1
      UniProtKB/TrEMBL
      A0A384P5V3, M0R0C6
      Related
      ENSP00000471146.2, ENST00000600480.2
      Conserved Domains (5) summary
      pfam09005
      Location:671685
      DUF1897; Domain of unknown function (DUF1897)
      cd22479
      Location:145215
      KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22482
      Location:233305
      KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22485
      Location:323390
      KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22488
      Location:426494
      KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    2. NM_001366300.1NP_001353229.1  far upstream element-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC011491, AC011539
      UniProtKB/TrEMBL
      A0A384P5V3
      Conserved Domains (5) summary
      pfam09005
      Location:646660
      DUF1897; Domain of unknown function (DUF1897)
      cd22479
      Location:145215
      KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22482
      Location:233305
      KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22485
      Location:323390
      KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22488
      Location:426494
      KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    3. NM_003685.3NP_003676.2  far upstream element-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003676.2

      Status: VALIDATED

      Source sequence(s)
      AA976482, AC011491, BC085004, BQ186683, CB216491, CF123311, DC388502, U94832
      Consensus CDS
      CCDS45936.1
      UniProtKB/Swiss-Prot
      O00301, Q59EZ9, Q5U4P6, Q92945, Q9UNT5, Q9UQH5
      UniProtKB/TrEMBL
      A0A384P5V3
      Related
      ENSP00000381216.2, ENST00000398148.7
      Conserved Domains (5) summary
      pfam09005
      Location:671685
      DUF1897; Domain of unknown function (DUF1897)
      cd22479
      Location:145215
      KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22482
      Location:233305
      KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22485
      Location:323390
      KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
      cd22488
      Location:426494
      KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6413102..6424811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6401987..6413694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)