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    ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ Homo sapiens (human) ]

    Gene ID: 8869, updated on 3-Dec-2024

    Summary

    Official Symbol
    ST3GAL5provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 5provided by HGNC
    Primary source
    HGNC:HGNC:10872
    See related
    Ensembl:ENSG00000115525 MIM:604402; AllianceGenome:HGNC:10872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SATI; SIAT9; SPDRS; ST3GalV; SIATGM3S; ST3Gal V
    Summary
    Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in adrenal (RPKM 17.6), thyroid (RPKM 16.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ST3GAL5 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85837120..85889034, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85839198..85891111, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86064243..86116157, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene atonal bHLH transcription factor 8 Neighboring gene microRNA 6071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:86023815-86024558 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:86031662-86031859 Neighboring gene uncharacterized LOC284950 Neighboring gene RN7SK pseudogene 83 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86115293-86115793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11709 Neighboring gene ST3GAL5 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC124906030

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    nucleocapsid gag HIV-1 NC upregulates ST3 beta-galactoside alpha-2,3-sialyltransferase 5 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in glycosphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    lactosylceramide alpha-2,3-sialyltransferase
    Names
    CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    GM3 synthase
    ST3 beta-galactoside alpha-23-sialyltransferase 5
    alpha 2,3-sialyltransferase V
    ganglioside GM3 synthase
    sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)
    NP_001035902.1
    NP_001341152.1
    NP_001341153.1
    NP_001341155.1
    NP_001341156.1
    NP_001341158.1
    NP_001341162.1
    NP_001341163.1
    NP_001341167.1
    NP_001341176.1
    NP_001341177.1
    NP_001350776.1
    NP_003887.3
    XP_047302193.1
    XP_047302194.1
    XP_047302195.1
    XP_047302196.1
    XP_047302197.1
    XP_054200372.1
    XP_054200373.1
    XP_054200374.1
    XP_054200375.1
    XP_054200376.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012807.2 RefSeqGene

      Range
      5044..56914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042437.2NP_001035902.1  lactosylceramide alpha-2,3-sialyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001035902.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a novel 5' exon compared to transcript variant 1, and encodes a shorter isoform (2) with a different N-terminus compared to isoform 1.
      Source sequence(s)
      AC105053, AY152815
      Consensus CDS
      CCDS42705.1
      UniProtKB/TrEMBL
      A0A1W2PRC6
      Related
      ENSP00000377397.3, ENST00000393808.8
      Conserved Domains (1) summary
      pfam00777
      Location:121387
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. NM_001354223.2NP_001341152.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Conserved Domains (1) summary
      pfam00777
      Location:15282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    3. NM_001354224.2NP_001341153.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Conserved Domains (1) summary
      pfam00777
      Location:15282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    4. NM_001354226.2NP_001341155.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Conserved Domains (1) summary
      pfam00777
      Location:15282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    5. NM_001354227.2NP_001341156.1  lactosylceramide alpha-2,3-sialyltransferase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Consensus CDS
      CCDS86856.1
      UniProtKB/TrEMBL
      A0A0S2Z4S6, A0A1W2PRC6
      Conserved Domains (1) summary
      pfam00777
      Location:127382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    6. NM_001354229.2NP_001341158.1  lactosylceramide alpha-2,3-sialyltransferase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Consensus CDS
      CCDS86856.1
      UniProtKB/TrEMBL
      A0A0S2Z4S6, A0A1W2PRC6
      Related
      ENSP00000491853.1, ENST00000638986.1
      Conserved Domains (1) summary
      pfam00777
      Location:127382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    7. NM_001354233.2NP_001341162.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Conserved Domains (1) summary
      pfam00777
      Location:15282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    8. NM_001354234.1NP_001341163.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Conserved Domains (1) summary
      pfam00777
      Location:15282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    9. NM_001354238.1NP_001341167.1  lactosylceramide alpha-2,3-sialyltransferase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC105053, AF105026
      Consensus CDS
      CCDS86856.1
      UniProtKB/TrEMBL
      A0A0S2Z4S6, A0A1W2PRC6
      Related
      ENSP00000377394.1, ENST00000393805.6
      Conserved Domains (1) summary
      pfam00777
      Location:127382
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    10. NM_001354247.1NP_001341176.1  lactosylceramide alpha-2,3-sialyltransferase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Related
      ENST00000640798.1
      Conserved Domains (1) summary
      pfam00777
      Location:1169
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    11. NM_001354248.1NP_001341177.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Conserved Domains (1) summary
      pfam00777
      Location:15282
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    12. NM_001363847.1NP_001350776.1  lactosylceramide alpha-2,3-sialyltransferase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC105053
      Consensus CDS
      CCDS86857.1
      UniProtKB/TrEMBL
      A0A0S2Z4Q7, A0A1W2PR45
      Related
      ENSP00000492045.1, ENST00000639119.1
      Conserved Domains (1) summary
      pfam00777
      Location:155357
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    13. NM_003896.4NP_003887.3  lactosylceramide alpha-2,3-sialyltransferase isoform 1

      See identical proteins and their annotated locations for NP_003887.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB018356, AC105053, AK001340, CA503200
      Consensus CDS
      CCDS1986.2
      UniProtKB/Swiss-Prot
      B3KM82, D6W5L9, O94902, Q53QU1, Q6NZX4, Q6YFL1, Q9UNP4
      UniProtKB/TrEMBL
      A0A1W2PRC6
      Related
      ENSP00000491316.1, ENST00000638572.2
      Conserved Domains (1) summary
      pfam00777
      Location:144410
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      85837120..85889034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446240.1XP_047302196.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    2. XM_047446238.1XP_047302194.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    3. XM_047446237.1XP_047302193.1  lactosylceramide alpha-2,3-sialyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z4S6, A0A1W2PRC6
    4. XM_047446239.1XP_047302195.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    5. XM_047446241.1XP_047302197.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A1W2PRD9
      Related
      ENSP00000492459.1, ENST00000640425.1

    RNA

    1. XR_007084237.1 RNA Sequence

    2. XR_007084231.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      85839198..85891111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344400.1XP_054200375.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    2. XM_054344398.1XP_054200373.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    3. XM_054344397.1XP_054200372.1  lactosylceramide alpha-2,3-sialyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A1W2PRC6
    4. XM_054344399.1XP_054200374.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    5. XM_054344401.1XP_054200376.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A1W2PRD9

    RNA

    1. XR_008486591.1 RNA Sequence

    2. XR_008486590.1 RNA Sequence