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    TRIP10 thyroid hormone receptor interactor 10 [ Homo sapiens (human) ]

    Gene ID: 9322, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRIP10provided by HGNC
    Official Full Name
    thyroid hormone receptor interactor 10provided by HGNC
    Primary source
    HGNC:HGNC:12304
    See related
    Ensembl:ENSG00000125733 MIM:604504; AllianceGenome:HGNC:12304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STP; CIP4; HSTP; STOT; TRIP-10
    Summary
    Enables identical protein binding activity. Predicted to be involved in signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 54.6), fat (RPKM 34.4) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIP10 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6739680..6751530)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6729071..6740925)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6739691..6751541)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697003-6697504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697505-6698004 Neighboring gene complement C3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6727893-6728394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6728395-6728894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9961 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:6735174-6735942 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736406-6736560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736926-6737087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6738248-6739016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6739785-6740552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6742783-6743702 Neighboring gene G protein-coupled receptor 108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6745754-6746254 Neighboring gene uncharacterized LOC124904623 Neighboring gene microRNA 6791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6760841-6761341 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6764936-6765836 Neighboring gene SH2 domain containing 3A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6772949-6773449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13864 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6782716-6782888 Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene MPRA-validated peak3307 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6801723-6802243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13866 Neighboring gene Sharpr-MPRA regulatory region 13171

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell communication NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cdc42-interacting protein 4
    Names
    TR-interacting protein 10
    protein Felic
    salt tolerant protein
    salt tolerator
    thyroid receptor-interacting protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288962.2NP_001275891.1  cdc42-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001275891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC008760, AF502289, AY081141, CB997985, DB198268
      Consensus CDS
      CCDS74271.1
      UniProtKB/Swiss-Prot
      B2R8A6, B7WP22, D6W645, O15184, Q15642, Q53G22, Q5TZN1, Q6FI24, Q8NFL1, Q8TCY1, Q8TDX3, Q96RJ1
      UniProtKB/TrEMBL
      A7VJC9
      Related
      ENSP00000320117.7, ENST00000313244.14
      Conserved Domains (3) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:395475
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:544598
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    2. NM_001288963.3NP_001275892.1  cdc42-interacting protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001275892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC008760, AF380114, AK313296, AY081141, CB997985, DB198268
      Consensus CDS
      CCDS74272.1
      UniProtKB/TrEMBL
      A7VJC9, W4VSQ9
      Related
      ENSP00000469360.1, ENST00000596758.5
      Conserved Domains (2) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:339419
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    3. NM_004240.4NP_004231.1  cdc42-interacting protein 4 isoform 2

      See identical proteins and their annotated locations for NP_004231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC008760, AK313296, AY081141, CB997985, DB198268
      Consensus CDS
      CCDS12172.1
      UniProtKB/TrEMBL
      A7VJC9
      Related
      ENSP00000320493.6, ENST00000313285.12
      Conserved Domains (3) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:339419
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:488542
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    RNA

    1. NR_110231.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB072596, AC008760, AK313296, AY081141, CB997985, DB198268

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6739680..6751530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722940.2XP_006723003.1  cdc42-interacting protein 4 isoform X1

      Conserved Domains (2) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:395475
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    2. XM_005259683.3XP_005259740.1  cdc42-interacting protein 4 isoform X2

      UniProtKB/TrEMBL
      M0R2H7
      Related
      ENSP00000472580.1, ENST00000600677.5
      Conserved Domains (1) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6729071..6740925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322670.1XP_054178645.1  cdc42-interacting protein 4 isoform X1

    2. XM_054322671.1XP_054178646.1  cdc42-interacting protein 4 isoform X2

      UniProtKB/TrEMBL
      M0R2H7