Npy1r neuropeptide Y receptor Y1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npy1rprovided by MGI
Official Full Name: neuropeptide Y receptor Y1provided by MGI
Primary source: MGI:MGI:104963
See related: Ensembl:ENSMUSG00000036437 AllianceGenome:MGI:104963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Npyr; Y1-R; NPY1-R
Summary: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within several processes, including feeding behavior; glucose metabolic process; and sensory perception of pain. Predicted to be located in axon and synaptic vesicle. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; immune system; and liver. Used to study obesity. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 14.0), cortex adult (RPKM 4.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.1; 8 33.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (67149595..67159452)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (66697149..66706800)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch.
Title: The plasticity of neuropeptide Y-Y1 receptor system on Tac2 neurons contributes to mechanical hyperknesis during chronic itch.
Hypothalamic NPY-Y1R Interacts with Gonadal Hormones in Protecting Female Mice against Obesity and Neuroinflammation.
Title: Hypothalamic NPY-Y1R Interacts with Gonadal Hormones in Protecting Female Mice against Obesity and Neuroinflammation.
NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression.
Title: NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression.
Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice.
Title: Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice.
Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions.
Title: Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions.
this study demonstrates that Y1 receptor signaling negatively regulates insulin release
Title: Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism.
This study showed that the Npy1r(Y5R-/-) male mice display decreased 5-hydroxytriptamine (5-HT) positive fibres and increased baseline neural activity in orbitofrontal cortex.
Title: Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram.
the lack of Y1Rs stimulates the formation of larger multinucleated osteoclasts in vitro with reduced bone-resorbing activity.
Title: Ablation of Y1 receptor impairs osteoclast bone-resorbing activity.
Knockdown of the Y1 receptor induces alkaline phosphatase activity and mineralization of MC3T3-E1 cells.
Title: Inhibition of neuropeptide Y Y1 receptor induces osteoblast differentiation in MC3T3‑E1 cells.
NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC) mobilization due to increased expression of HSPC maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9) activity in bone marrow.
Title: Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (11) 1 citation

General gene information

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Markers

PMC28100P1 (e-PCR)
- UniSTS:272402

D63818 (e-PCR)
- UniSTS:163439

Npy1r (e-PCR), detects polymorphism
- UniSTS:531347

Npy1r (e-PCR), detects polymorphism
- UniSTS:256982

Npy1r (e-PCR), detects polymorphism
- UniSTS:256983

UniSTS:256984 (e-PCR)
- UniSTS:256984

Npy1r (e-PCR), detects polymorphism
- UniSTS:256984

Npy1r (e-PCR), detects polymorphism
- UniSTS:256985

Npy1r (e-PCR), detects polymorphism
- UniSTS:256986

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide YY receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to morphine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling via neuropeptide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropeptide Y receptor type 1

Names: NPY-1 receptor; neuropeptide Y receptor subtype

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358955.1 → NP_001345884.1 neuropeptide Y receptor type 1

Status: VALIDATED

Source sequence(s)

AC116731

Consensus CDS

CCDS22336.1

UniProtKB/Swiss-Prot

Q04573, Q61993

UniProtKB/TrEMBL

Q3V1K5

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_010934.4 → NP_035064.1 neuropeptide Y receptor type 1

See identical proteins and their annotated locations for NP_035064.1

Status: VALIDATED

Source sequence(s)

AC116731

Consensus CDS

CCDS22336.1

UniProtKB/Swiss-Prot

Q04573, Q61993

UniProtKB/TrEMBL

Q3V1K5

Related

ENSMUSP00000045530.6, ENSMUST00000039303.7

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

67149595..67159452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509594.5 → XP_006509657.1 neuropeptide Y receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_006509657.1

UniProtKB/Swiss-Prot

Q04573, Q61993

UniProtKB/TrEMBL

Q3V1K5

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006509595.5 → XP_006509658.1 neuropeptide Y receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_006509658.1

UniProtKB/Swiss-Prot

Q04573, Q61993

UniProtKB/TrEMBL

Q3V1K5

Related

ENSMUSP00000148417.2, ENSMUST00000212588.2

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036153812.1 → XP_036009705.1 neuropeptide Y receptor type 1 isoform X1

UniProtKB/Swiss-Prot

Q04573, Q61993

UniProtKB/TrEMBL

Q3V1K5

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036153811.1 → XP_036009704.1 neuropeptide Y receptor type 1 isoform X1

UniProtKB/Swiss-Prot

Q04573, Q61993

UniProtKB/TrEMBL

Q3V1K5

Conserved Domains (1) summary

cd15395
Location:40 → 330

7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors