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    Rdx radixin [ Mus musculus (house mouse) ]

    Gene ID: 19684, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rdxprovided by MGI
    Official Full Name
    radixinprovided by MGI
    Primary source
    MGI:MGI:97887
    See related
    Ensembl:ENSMUSG00000032050 AllianceGenome:MGI:97887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein domain specific binding activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of G1/S transition of mitotic cell cycle; and regulation of postsynaptic neurotransmitter receptor diffusion trapping. Acts upstream of or within apical protein localization and microvillus assembly. Located in several cellular components, including lamellipodium; ruffle; and stereocilium base. Colocalizes with plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study Dubin-Johnson syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.7), placenta adult (RPKM 29.6) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Rdx in Genome Data Viewer
    Location:
    9 A5.3; 9 28.62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51958450..52000038)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (52047150..52088738)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene STARR-seq mESC enhancer starr_24133 Neighboring gene ferredoxin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene zinc finger CCCH type containing 12C Neighboring gene microRNA 6244 Neighboring gene STARR-positive B cell enhancer ABC_E3829 Neighboring gene predicted gene, 25562

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables actin binding  
    enables actin binding  
    enables actin binding  
    enables cell adhesion molecule binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein kinase A binding  
    Items 1 - 25 of 36
    Process Evidence Code Pubs
    involved_in actin filament capping  
    acts_upstream_of_or_within apical protein localization PubMed 
    involved_in apical protein localization  
    involved_in barbed-end actin filament capping  
    involved_in cellular response to thyroid hormone stimulus PubMed 
    involved_in cellular response to thyroid hormone stimulus  
    involved_in establishment of endothelial barrier  
    involved_in establishment of protein localization PubMed 
    involved_in establishment of protein localization to plasma membrane  
    acts_upstream_of_or_within microvillus assembly PubMed 
    involved_in negative regulation of GTPase activity  
    involved_in negative regulation of adherens junction organization  
    involved_in negative regulation of cell size  
    involved_in negative regulation of homotypic cell-cell adhesion  
    involved_in positive regulation of G1/S transition of mitotic cell cycle PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of early endosome to late endosome transport  
    involved_in positive regulation of early endosome to late endosome transport  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein localization to early endosome  
    involved_in positive regulation of protein localization to early endosome  
    involved_in protein kinase A signaling  
    involved_in protein localization to plasma membrane  
    involved_in regulation of GTPase activity  
    involved_in regulation of Rap protein signal transduction  
    involved_in regulation of actin filament bundle assembly  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of cell size  
    involved_in regulation of organelle assembly  
    involved_in regulation of organelle assembly  
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping PubMed 
    involved_in regulation of ruffle assembly  
    Items 1 - 25 of 36
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in T-tubule  
    is_active_in adherens junction  
    located_in adherens junction  
    is_active_in apical part of cell  
    located_in apical part of cell PubMed 
    located_in apical plasma membrane  
    located_in cell periphery  
    located_in cell tip  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cortical actin cytoskeleton PubMed 
    located_in cortical actin cytoskeleton  
    located_in cytosol  
    is_active_in filopodium  
    located_in filopodium PubMed 
    located_in filopodium  
    colocalizes_with focal adhesion  
    located_in lamellipodium PubMed 
    located_in lamellipodium  
    is_active_in microvillus  
    located_in microvillus PubMed 
    located_in microvillus  
    located_in midbody  
    located_in myelin sheath PubMed 
    colocalizes_with plasma membrane PubMed 
    located_in plasma membrane  
    located_in ruffle PubMed 
    located_in stereocilium PubMed 
    located_in stereocilium base PubMed 
    Items 1 - 20 of 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104616.2NP_001098086.1  radixin isoform a

      See identical proteins and their annotated locations for NP_001098086.1

      Status: VALIDATED

      Source sequence(s)
      AC159881, CT009732
      Consensus CDS
      CCDS40634.1
      UniProtKB/Swiss-Prot
      P26043, Q3TS85, Q9QW27
      UniProtKB/TrEMBL
      Q3UJJ8
      Related
      ENSMUSP00000128249.2, ENSMUST00000163153.9
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family
    2. NM_001104617.2NP_001098087.1  radixin isoform b

      See identical proteins and their annotated locations for NP_001098087.1

      Status: VALIDATED

      Source sequence(s)
      AC159881
      Consensus CDS
      CCDS52793.1
      UniProtKB/TrEMBL
      Q7TSG6, Q8C2N4
      Related
      ENSMUSP00000055303.10, ENSMUST00000061352.11
      Conserved Domains (4) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:91206
      FERM_M; FERM central domain
      pfam09379
      Location:971
      FERM_N; FERM N-terminal domain
    3. NM_001433750.1NP_001420679.1  radixin isoform c

      Status: VALIDATED

      Source sequence(s)
      AC159881, CT009732
      UniProtKB/TrEMBL
      A0A5F8MPB9, Q3UJJ8
    4. NM_001433751.1NP_001420680.1  radixin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC159881, CT009732
      UniProtKB/TrEMBL
      Q3UJJ8
    5. NM_009041.4NP_033067.2  radixin isoform a

      See identical proteins and their annotated locations for NP_033067.2

      Status: VALIDATED

      Source sequence(s)
      AC159881, CT009732
      Consensus CDS
      CCDS40634.1
      UniProtKB/Swiss-Prot
      P26043, Q3TS85, Q9QW27
      UniProtKB/TrEMBL
      Q3UJJ8
      Related
      ENSMUSP00000000590.9, ENSMUST00000000590.16
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      51958450..52000038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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