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    Gadl1 glutamate decarboxylase-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367181, updated on 3-Dec-2024

    Summary

    Symbol
    Gadl1provided by RGD
    Full Name
    glutamate decarboxylase-like 1provided by RGD
    Primary source
    RGD:1565145
    See related
    EnsemblRapid:ENSRNOG00000067908 AllianceGenome:RGD:1565145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565145
    Summary
    Predicted to enable carboxy-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 185.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gadl1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (124483736..124663815)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (115605609..115785676)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (123989822..124301366)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480108 Neighboring gene uncharacterized LOC120094283 Neighboring gene transforming growth factor, beta receptor 2 Neighboring gene uncharacterized LOC120094284

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    acidic amino acid decarboxylase GADL1; glutamate decarboxylase-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430390.1NP_001417319.1  glutamate decarboxylase-like 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AWC8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      124483736..124663815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766660.4XP_008764882.3  acidic amino acid decarboxylase GADL1 isoform X1

      Related
      ENSRNOP00000102931.1, ENSRNOT00000172052.1
      Conserved Domains (1) summary
      cd06450
      Location:196596
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    2. XM_039082694.2XP_038938622.1  acidic amino acid decarboxylase GADL1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AWC8
      Conserved Domains (1) summary
      cd06450
      Location:98498
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    3. XM_039082695.2XP_038938623.1  acidic amino acid decarboxylase GADL1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AWC8
      Related
      ENSRNOP00000097428.2, ENSRNOT00000117193.2
      Conserved Domains (1) summary
      cd06450
      Location:98498
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...