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    Mettl13 methyltransferase 13, eEF1A N-terminus and K55 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289159, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mettl13provided by RGD
    Official Full Name
    methyltransferase 13, eEF1A N-terminus and K55provided by RGD
    Primary source
    RGD:1311526
    See related
    EnsemblRapid:ENSRNOG00000003042 AllianceGenome:RGD:1311526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eef1aknmt; RGD1311526
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; mitochondrion; and nucleus. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 52.4), Thymus (RPKM 52.1) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mettl13 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77419393..77433228, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74886151..74899937, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80427595..80441353, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555077 Neighboring gene protein CEBPZOS-like Neighboring gene uncharacterized LOC120096299 Neighboring gene vesicle-associated membrane protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eEF1A lysine and N-terminal methyltransferase
    Names
    methyltransferase 13, eEF1A lysine and N-terminal methyltransferase
    methyltransferase like 13
    methyltransferase-like protein 13
    NP_001127973.1
    XP_006250214.1
    XP_038946413.1
    XP_038946414.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134501.2NP_001127973.1  eEF1A lysine and N-terminal methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001127973.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZV13, A6ID93
      Related
      ENSRNOP00000082496.1, ENSRNOT00000063902.4
      Conserved Domains (3) summary
      COG0500
      Location:507656
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08241
      Location:53158
      Methyltransf_11; Methyltransferase domain
      cl17173
      Location:506679
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001434085.1NP_001421014.1  eEF1A lysine and N-terminal methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
    3. NM_001434086.1NP_001421015.1  eEF1A lysine and N-terminal methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      77419393..77433228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090485.2XP_038946413.1  eEF1A lysine and N-terminal methyltransferase isoform X1

      Conserved Domains (2) summary
      pfam13649
      Location:52154
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:500673
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006250152.5XP_006250214.1  eEF1A lysine and N-terminal methyltransferase isoform X1

      Conserved Domains (2) summary
      pfam13649
      Location:52154
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:500673
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_039090486.1XP_038946414.1  eEF1A lysine and N-terminal methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:183356
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...